Acute myocardial infarction patient-derived endothelial cells display a strong mitochondrial proton coupling with excess ROS production, enhanced glutamine metabolism and a carbon source switch from glucose to glutamine.
The optimal allocation strategy prioritizes funding to high-transmission settings in sub-Saharan Africa, but highlights a trade-off between reducing clinical malaria burden and reducing the global population at risk of malaria.
Sasithon Pukrittayakamee, Podjanee Jittamala ... Nicholas J White
A full radical curative dose of primaquine can be given to fully glucose-6-phosphate dehydrogenase-deficient males safely using an ascending dose regimen.
Teneurin-2, a synaptic organizer, localizes to microtubule-rich inhibitory synapses and recruits microtubules via interaction with end-binding proteins, and this mechanism enables GABAA receptors exocytosis.
Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco
RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.