41 results found
    1. Microbiology and Infectious Disease

    Efficacy and mechanism of actions of cipargamin as an antibabesial drug candidate

    Hang Li, Shengwei Ji ... Xuenan Xuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
  1. Ben Barres Spotlight Awards: Announcing the winners for 2024

    Fourteen researchers, eight of them as authors of Reviewed Preprints, have been recognised in the awards’ most geographically diverse cohort to date.
    1. Medicine

    Autonomous metabolic reprogramming and oxidative stress characterize endothelial dysfunction in acute myocardial infarction

    Erika Zodda, Olga Tura-Ceide ... Marta Cascante
    Acute myocardial infarction patient-derived endothelial cells display a strong mitochondrial proton coupling with excess ROS production, enhanced glutamine metabolism and a carbon source switch from glucose to glutamine.
    1. Epidemiology and Global Health

    Modeling resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication

    Nora Schmit, Hillary M Topazian ... Azra C Ghani
    The optimal allocation strategy prioritizes funding to high-transmission settings in sub-Saharan Africa, but highlights a trade-off between reducing clinical malaria burden and reducing the global population at risk of malaria.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis'

    Raman Sharma, Chao Chen ... Panayota Bird
    We are writing to comment on the article by Watson et al., 2022 about the antimalarial drug tafenoquine.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Response to comment on 'The clinical pharmacology of tafenoquine in the radical cure of Plasmodium vivax malaria: An individual patient data meta-analysis'

    James A Watson, Robert J Commons ... Nicholas J White
    We are writing to respond to comment by Sharma et al, 2024 on our article about the antimalarial drug tafenoquine.
    1. Epidemiology and Global Health
    2. Medicine

    Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

    Sasithon Pukrittayakamee, Podjanee Jittamala ... Nicholas J White
    A full radical curative dose of primaquine can be given to fully glucose-6-phosphate dehydrogenase-deficient males safely using an ascending dose regimen.
    1. Cell Biology
    2. Neuroscience

    Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis

    Sotaro Ichinose, Yoshihiro Susuki ... Hirohide Iwasaki
    Teneurin-2, a synaptic organizer, localizes to microtubule-rich inhibitory synapses and recruits microtubules via interaction with end-binding proteins, and this mechanism enables GABAA receptors exocytosis.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The Dantu blood group prevents parasite growth in vivo: Evidence from a controlled human malaria infection study

    Silvia N Kariuki, Alexander W Macharia ... Thomas N Williams
    Strongly protective effect conferred by the Dantu blood group variant against early, non-clinical, Plasmodium falciparum malaria infections in vivo.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

    Minato Hirano, Gaddiel Galarza-Muñoz ... Mariano A Garcia-Blanco
    RNA processing regulates gene expression of the key transcription factor FOXP3 in T regulatory cells impacting immune tolerance and susceptibility to autoimmune disease.

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