41 results found
    1. Cell Biology
    2. Medicine

    Quantitative mapping of human hair greying and reversal in relation to life stress

    Ayelet M Rosenberg, Shannon Rausser ... Martin Picard
    A method to profile hair pigmentation patterns establishes a new approach for psychobiological studies and links metabolic changes to greying in humans.
    1. Cell Biology
    2. Neuroscience

    Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis

    Sotaro Ichinose, Yoshihiro Susuki ... Hirohide Iwasaki
    Teneurin-2, a synaptic organizer, localizes to microtubule-rich inhibitory synapses and recruits microtubules via interaction with end-binding proteins, and this mechanism enables GABAA receptors exocytosis.
    1. Cancer Biology
    2. Microbiology and Infectious Disease

    YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

    Joshua Hatterschide, Paola Castagnino ... Elizabeth A White
    Papillomavirus E7 proteins activate the YAP1 oncogene in basal epithelial cells by degrading PTPN14, in doing so promoting basal cell retention and contributing to carcinogenesis.
    1. Microbiology and Infectious Disease

    Efficacy and mechanism of actions of cipargamin as an antibabesial drug candidate

    Hang Li, Shengwei Ji ... Xuenan Xuan
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Convincing
    1. Microbiology and Infectious Disease

    The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

    Devendra Kumar Gupta, Laurent Dembele ... Thierry Tidiane Diagana
    LISP2 expression marks the beginning of awakening of dormant hypnozoite to developing malaria liver stages, which are susceptible to a novel prophylactic drug, Plasmodium PI4K inhibitor.
    1. Microbiology and Infectious Disease

    Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

    Nicole L Bertschi, Annemarie Voorberg-van der Wel ... Guglielmo Roma
    Transcriptome profiling of malaria liver-stage parasites provides unprecedented knowledge on genes and pathways expressed in truly dormant hypnozoites and indicates that dormancy is associated with a switch in energy metabolism.
    1. Epidemiology and Global Health

    Modeling resource allocation strategies for insecticide-treated bed nets to achieve malaria eradication

    Nora Schmit, Hillary M Topazian ... Azra C Ghani
    The optimal allocation strategy prioritizes funding to high-transmission settings in sub-Saharan Africa, but highlights a trade-off between reducing clinical malaria burden and reducing the global population at risk of malaria.
    1. Epidemiology and Global Health

    Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure

    Isabel Rodriguez-Barraquer, Emmanuel Arinaitwe ... Bryan Greenhouse
    Analyses of detailed clinical and entomological data from cohort studies reveal how anti-parasite and anti-disease immunity against P. falciparum develop as a function of age and transmission intensity.
    1. Cell Biology
    2. Medicine

    An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming

    Hong Wang, Xueping Wan ... Libin Liu
    A non-canonical p53 function in adipocyte plays a critical role in energy homeostasis and is involved in obesity-associated metabolic dysfunctions.
    1. Developmental Biology
    2. Evolutionary Biology

    Cavefish cope with environmental hypoxia by developing more erythrocytes and overexpression of hypoxia-inducible genes

    Corine M van der Weele, William R Jeffery
    Astyanax mexicanus cavefish cope with hypoxic environments by expanding embryonic hematopoietic domains, increasing the capacity for erythrocyte development, and constitutive overexpression of hypoxia-inducible genes.

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