878 results found
    1. Neuroscience

    A network of autism linked genes stabilizes two pools of synaptic GABAA receptors

    Xia-Jing Tong et al.
    Mobile and immobile GABAA receptors in the C. elegans neuromuscular synapse are stabilized by two distinct protein scaffolds.
    1. Cell Biology
    2. Neuroscience

    Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines

    Sonia Afroz et al.
    Extrasynaptic GABAA receptors that emerge at puberty trigger adolescent synaptic pruning; pruning is prevented and cognition is impaired if the receptors are absent.
    1. Structural Biology and Molecular Biophysics

    Site-specific effects of neurosteroids on GABAA receptor activation and desensitization

    Yusuke Sugasawa et al.
    Differential, state-dependent occupancy of three discrete binding sites on α1β3 GABAA receptors determines whether a specific neurosteroid analogue potentiates or inhibits GABA-elicited currents or competitively antagonizes neurosteroid action.
    1. Structural Biology and Molecular Biophysics

    A critical residue in the α1M2–M3 linker regulating mammalian GABAA receptor pore gating by diazepam

    Joseph W Nors et al.
    The role of an important gating domain in linkage between the benzodiazepine drug-binding site and the pore gate in GABAA receptors.
    1. Neuroscience

    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

    Katalin Kerti-Szigeti, Zoltan Nusser
    All perisomatic GABAergic synpases on hippocampal pyramidal cells have a similar GABAA receptor subunit composition.
    1. Neuroscience

    Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

    Paul F Kramer et al.
    GABA-A receptors on dopamine neuron axons not only depolarize the membrane but also limit action potential propagation, an effect potentiated by positive allosteric modulators of GABA-A receptors like diazepam (Valium).
    1. Neuroscience

    Assembly rules for GABAA receptor complexes in the brain

    James S Martenson et al.
    A novel GABAAR assembly pathway that promotes synaptic inhibition is established and provides a molecular explanation for how GABAARs with distinct subunit compositions display distinct subcellular distributions.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

    Swastik Phulera et al.
    Structure of the triheteromeric α1β1γ2S GABAA receptor in complex with GABA illuminates the principles of receptor assembly and agonist binding.
    1. Neuroscience

    Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network

    Sam A Booker et al.
    Presynaptic GABAB receptors are highly expressed and strongly suppress synaptic transmission at the input and output of hippocampal somatostatin interneurons.
    1. Neuroscience

    Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN

    Fabian Philippart, Zayd M Khaliq
    The sodium leak NALCN channel functions as a core effector of GABA-B and D2 receptors that is used along with GIRK channels to regulate action potential firing in dopamine neurons.

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