299 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Combinatorial chromatin dynamics foster accurate cardiopharyngeal fate choices

    Claudia Racioppi et al.
    ATAC-seq, CRISPR/Cas9 mutagenesis, reporter and gene expression assays revealed dynamic chromatin accessibility profiles governing differential gene expression during heart vs. pharyngeal muscle fate choices in the powerful chordate model Ciona.
    1. Cell Biology

    A novel mode of capping protein-regulation by twinfilin

    Adam B Johnston et al.
    Twinfilin functions as a pro-capping ligand of capping protein, dynamically competing with inhibitory ligands of capping proteinto control cellular actin assembly.
    1. Developmental Biology

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung et al.
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation

    Qin Li et al.
    PTBP2 ensures that adult protein variants are expressed only in mature neurons through regulation of alternative splicing during early neuronal development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

    Jennifer Jung et al.
    An image-based multiplex autophagosome RNAi screen targeting all Rab GTPases as well as their GAPs and GEFs identifies the Rab GEF SMCR8 as multifaceted autophagy modulator, which regulates kinase activity and gene expression of ULK1.
    1. Structural Biology and Molecular Biophysics

    Structural basis of ribosomal peptide macrocyclization in plants

    Joel Haywood et al.
    The first crystal structure of an active plant asparaginyl endopeptidase reveals a tetrahedral intermediate state in its active site, which may help to explain why these enzymes have been independently recruited to perform peptide macrocyclization.
    1. Microbiology and Infectious Disease
    2. Plant Biology

    An effector of the Irish potato famine pathogen antagonizes a host autophagy cargo receptor

    Yasin F Dagdas et al.
    A plant pathogen effector evolved a short linear motif to subvert autophagic defenses by antagonising a host cargo receptor.
    1. Cell Biology

    The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins

    Matthew J Shurtleff et al.
    The ER membrane protein complex promotes the biogenesis of a subset multipass membrane proteins enriched for transporters and other proteins with destabilizing features in transmembrane domains.
    1. Genetics and Genomics

    A regulatory pathway that selectively up-regulates elongasome function in the absence of class A PBPs

    Yesha Patel et al.
    Balanced peptidoglycan synthesis requires regulators, including sigma-I and WalKR, that coordinate the diffusive action of class A PBPs and the directional motion of the MreB-directed elongasome.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor

    Anastasiia Stratiievska et al.
    A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli.

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