428 results found
    1. Neuroscience

    A network of autism linked genes stabilizes two pools of synaptic GABAA receptors

    Xia-Jing Tong et al.
    Mobile and immobile GABAA receptors in the C. elegans neuromuscular synapse are stabilized by two distinct protein scaffolds.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

    Swastik Phulera et al.
    Structure of the triheteromeric α1β1γ2S GABAA receptor in complex with GABA illuminates the principles of receptor assembly and agonist binding.
    1. Cell Biology
    2. Neuroscience

    Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines

    Sonia Afroz et al.
    Extrasynaptic GABAA receptors that emerge at puberty trigger adolescent synaptic pruning; pruning is prevented and cognition is impaired if the receptors are absent.
    1. Neuroscience

    Assembly rules for GABAA receptor complexes in the brain

    James S Martenson et al.
    A novel GABAAR assembly pathway that promotes synaptic inhibition is established and provides a molecular explanation for how GABAARs with distinct subunit compositions display distinct subcellular distributions.
    1. Neuroscience

    Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

    Katalin Kerti-Szigeti, Zoltan Nusser
    All perisomatic GABAergic synpases on hippocampal pyramidal cells have a similar GABAA receptor subunit composition.
    1. Neuroscience

    Gi/o protein-coupled receptors in dopamine neurons inhibit the sodium leak channel NALCN

    Fabian Philippart, Zayd M Khaliq
    The sodium leak NALCN channel functions as a core effector of GABA-B and D2 receptors that is used along with GIRK channels to regulate action potential firing in dopamine neurons.
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter et al.
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Neuroscience

    Modulation of anxiety and fear via distinct intrahippocampal circuits

    Elif Engin et al.
    The hippocampus features a double dissociation in its circuits with respect to the regulation of fear and anxiety, with CA3 and the dentate gyrus implicated in anxiety and CA1 in fear.
    1. Neuroscience

    Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

    Ming Chen et al.
    Experiments examining the actions of morphine on single neurons from one of the brain's reward centers, the VTA, reveal the mechanism by which the drug exerts its hedonic effects.
    1. Neuroscience

    The role of piriform associative connections in odor categorization

    Xiaojun Bao et al.
    Pharmacological fMRI reveals that associative connections contribute to odor categorization by supporting discrimination and generalization at different stages of the human olfactory system.

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