141 results found
    1. Developmental Biology
    2. Neuroscience

    Dual midbrain and forebrain origins of thalamic inhibitory interneurons

    Polona Jager et al.
    Thalamic interneurons in the mouse thalamus are often overlooked because of their extremely low numbers, however they are developmentally complex and related to those of larger-brained species.
    1. Developmental Biology
    2. Neuroscience

    Neurotransmitter identity is acquired in a lineage-restricted manner in the Drosophila CNS

    Haluk Lacin et al.
    Lineally related neurons in the adult Drosophila ventral nerve cord use the same neurotransmitter to communicate with other neurons.
    1. Developmental Biology

    Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain

    Ko W Currie et al.
    Planarian brain neurons modulate their turnover by signaling to nearby stem cells.
    1. Developmental Biology

    Specification of diverse cell types during early neurogenesis of the mouse cerebellum

    John W Wizeman et al.
    Single-cell RNA sequencing resolves inter- and intra-population heterogeneity, identifies rare cell types, and reconstructs specification trajectories during early neurogenesis of the mouse cerebellum.
    1. Developmental Biology
    2. Neuroscience

    Olig3 regulates early cerebellar development

    Elijah D Lowenstein et al.
    The transcription factor Olig3 safeguards the correct specification of early born cerebellar neuron derivatives and curtails an inhibitory interneuron differentiation program.
    1. Stem Cells and Regenerative Medicine

    Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons

    Joseph Herdy et al.
    An unbiased RNAseq based strategy to identify targetable pathways and a streamlined lentiviral system provide a state of the art advance on direct fibroblast to neuron conversion.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

    Arantxa Cebrian-Silla et al.
    Adult neural stem cells differ in the types of neurons they generate according to their location and new territories and genes associated with dorsal and ventral neurogenic lineages in the adult mouse brain are revealed.
    1. Developmental Biology
    2. Neuroscience

    Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

    Maria-Daniela Cirnaru et al.
    RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.
    1. Neuroscience

    Beyond excitation/inhibition imbalance in multidimensional models of neural circuit changes in brain disorders

    Cian O'Donnell et al.
    Computational modeling and analysis of mouse neural population data finds that the excitation/inhibition imbalance theory of brain disorders is too limited to account for key changes in neural activity statistics.
    1. Developmental Biology
    2. Neuroscience

    Conserved and divergent development of brainstem vestibular and auditory nuclei

    Marcela Lipovsek, Richard JT Wingate
    The development of brainstem auditory nuclei echoes the divergent evolutionary history of amniote auditory systems.

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