A computational model of the thalamocortical network explains sleep stages by the coordinated variations in the level of neuromodulators and predicts differences of sleep pattern in human, cat and mouse recordings.
The activity of a set of GABAergic neurons is causally linked with a locomotory pattern in moving animals, and the mechanisms underlying the neuromodulatory role of GABA are illuminated.
Central thalamus relay neurons dynamically switch the activity of cortical and subcortical networks at distinct frequencies, providing a mechanism for this region's role in arousal regulation.
Optogenetic and electrical low-frequency stimulation in the sclerotic hippocampus prevents the emergence of spontaneous focal and evoked generalized seizures in a mouse epilepsy model.
Vasoactive intestinal peptide-expressing GABAergic interneurons in cerebral cortex express the sodium channel subunit Nav1.1, and a defined subset of VIP interneurons are dysfunctional in a mouse model of Dravet syndrome.
In mammals, the vesicular glutamate transporter 1 acquired a proline-rich sequence that negatively regulates the spontaneous release of glutamate by reducing the exchange of synaptic vesicles along the axon.
Simultaneous quantification of each of the main motor programs in the roundworm C. elegans yields new insights into the neural mechanisms that coordinate animal behavior.
Midbrain dopamine neurons use sophisticated secretory machinery to establish specialized sites for action potential-evoked release of dopamine from their cell bodies and dendrites.
Threonine promotes sleep via down-regulation of metabotropic GABA transmission in the ellipsoid body R2 neurons that generate homeostatic sleep drive in Drosophila.
