1,593 results found
    1. Cell Biology

    GAS5 protects against osteoporosis by targeting UPF1/SMAD7 axis in osteoblast differentiation

    Ming Li, Zhongyu Xie ... Huiyong Shen
    GAS5 is related to osteoporosis by regulating the differentiation of bone marrow stromal cells that acts as a promising treatment target for osteoporosis.
    1. Immunology and Inflammation

    Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

    Zihao Yao, Weizhong Qi ... Haiyan Zhang
    Down-regulation of GAS6 by M1 macrophages resulted in impaired efferocytosis for synovial apoptotic cells, causing synovial hyperplasia and obesity-associated OA development.
    1. Plant Biology

    Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

    Katherine Noelani Chang, Shan Zhong ... Joseph R Ecker
    The plant hormone ethylene regulates the expression of multiple genes in the model plant Arabidopsis, including those that respond to other hormones.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Differential TAM receptor–ligand–phospholipid interactions delimit differential TAM bioactivities

    Erin D Lew, Jennifer Oh ... Greg Lemke
    Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.
    1. Microbiology and Infectious Disease

    Community composition shapes microbial-specific phenotypes in a cystic fibrosis polymicrobial model system

    Fabrice Jean-Pierre, Thomas H Hampton ... George A O'Toole
    A cystic fibrosis (CF) lung microbiome-informed in vitro polymicrobial system allows for a mechanistic understanding of community-specific tolerance of Pseudomonas aeruginosa to a front-line CF antimicrobial.
    1. Neuroscience

    Sleep Apnea: When the tongue runs out of gas

    Lila Wollman, Ralph Fregosi
    The transmission of signals from the brain to the tongue to control breathing depends, in part, on the balance between two gaseous molecules.
    Version of Record
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    1. Neuroscience

    Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

    Ryan T Dosumu-Johnson, Andrea E Cocoran ... Susan M Dymecki
    Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.
    1. Evolutionary Biology

    Isometric spiracular scaling in scarab beetles—implications for diffusive and advective oxygen transport

    Julian M Wagner, C Jaco Klok ... Jon F Harrison
    Diffusion but not advection becomes increasingly challenging for gas transport across insect spiracles as body size increases.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi–Goutières syndrome

    Yoong Wearn Lim, Lionel A Sanz ... Frédéric Chédin
    Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.

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