GAS5 is related to osteoporosis by regulating the differentiation of bone marrow stromal cells that acts as a promising treatment target for osteoporosis.
Down-regulation of GAS6 by M1 macrophages resulted in impaired efferocytosis for synovial apoptotic cells, causing synovial hyperplasia and obesity-associated OA development.
Signaling by TAM receptor tyrosine kinases requires the coincident engagement of a TAM ligand with both its receptor and the phospholipid phosphatidylserine.
Fabrice Jean-Pierre, Thomas H Hampton ... George A O'Toole
A cystic fibrosis (CF) lung microbiome-informed in vitro polymicrobial system allows for a mechanistic understanding of community-specific tolerance of Pseudomonas aeruginosa to a front-line CF antimicrobial.
Ryan T Dosumu-Johnson, Andrea E Cocoran ... Susan M Dymecki
Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.
Yoong Wearn Lim, Lionel A Sanz ... Frédéric Chédin
Global epigenetic perturbations and accumulation of RNA:DNA hybrids are two novel hallmarks of the lupus-like inflammatory disorder Aicardi-Goutières syndrome.