Astrocyte microdomain calcium transients are mediated by TrpML, stimulated by ROS and tyramine, and mediate astrocyte–tracheal interactions in CNS gas exchange.
Mehdi Goudarzi, Kathryn Berg ... Alexander F Schier
Defining the biological functions of long non-coding RNAs, individually or as a class, and teasing apart the role of underlying genomic sequences remains the biggest challenge for this field.
Engineered mesenchymal stem cells (MSCs) could produce mutant β-galactosidase and trigger nitric oxide (NO) release when the NO prodrug is systemically administered, which can achieve NO release in a precise spatiotemporal manner and augment the therapeutic efficiency of MSCs.
The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.
Ana Sofia Pinheiro, Vasilios Tsarouhas ... Christos Samakovlis
During tracheal morphogenesis, the scavenger receptor Emp senses and responds to luminal cargo levels by initiating apical membrane endocytosis along the longitudinal tube axis to restrict airway elongation.
Elin Näsström, Christopher M Parry ... Stephen Baker
Mass spectrometry on plasma from patients with typhoid fever and other febrile disease identified and validated 24 metabolites that can distinguish typhoid from other febrile diseases, providing a new approach for typhoid diagnostics.
Xue-Ping Wang, Deidra M Balchak ... Ossama B Kashlan
Proteolytic activation of a sodium-permeable channel that aids in gas exchange and fluid homeostasis likely evolved at the water to land transition in vertebrates.
