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    1. Developmental Biology

    Condensin I subunit Cap-G is essential for proper gene expression during the maturation of post-mitotic neurons

    Amira Hassan, Pablo Araguas Rodriguez ... Tony D Southall
    The condensin I subunit Cap-G is expressed in post-mitotic neurons and its removal, especially from less mature neurons, results in gene expression changes, reduced survival and behavioural defects in Drosophila.
    1. Neuroscience

    Inhibitory control of frontal metastability sets the temporal signature of cognition

    Vincent Fontanier, Matthieu Sarazin ... Emmanuel Procyk
    Single unit recordings in monkeys and biophysical modelling demonstrate that local inhibitory-controlled metastable neural states specify the temporal organization of cognitive functions in frontal areas.
    1. Plant Biology

    The Rhizobial effector NopT targets Nod factor receptors to regulate symbiosis in Lotus japonicus

    Hanbin Bao, Yanan Wang ... Yangrong Cao
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Mesoscale functional architecture in medial posterior parietal cortex

    Riichiro Hira, Leah B Townsend ... Spencer LaVere Smith
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Evolutionary Biology
    2. Genetics and Genomics

    Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae

    Fabien Duveau, Petra Vande Zande ... Patricia J Wittkopp
    Mapping mutations affecting gene expression within the yeast genome and within a gene regulatory network reveals properties of the raw material for regulatory variation.
    1. Microbiology and Infectious Disease

    SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle

    Alice L Herneisen, Michelle L Peters ... Sebastian Lourido
    Genetic and proteomic analyses reveal that the SPARK kinase, which is a regulator of key life-cycle transitions in the parasite Toxoplasma gondii, complexes with an elongin-like protein to regulate several important AGC-family kinases.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Highly regulated, diversifying NTP-dependent biological conflict systems with implications for the emergence of multicellularity

    Gurmeet Kaur, A Maxwell Burroughs ... L Aravind
    Multicellular and socially aggregating prokaryotes contain previously undescribed, chaperone-based systems predicted to mediate defensive biological conflicts, several components of which are thematically similar antecedents of eukaryotic apoptosis pathways.
    1. Developmental Biology

    Fat body-derived cytokine Upd2 controls disciplined migration of tracheal stem cells in Drosophila

    Pengzhen Dong, Yue Li ... Hai Huang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Ecology

    The LOTUS initiative for open knowledge management in natural products research

    Adriano Rutz, Maria Sorokina ... Pierre-Marie Allard
    The LOTUS initiative builds, through the Wikidata knowledge graph, a virtuous cycle of data sharing practices for natural products research.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Bacterial death and TRADD-N domains help define novel apoptosis and immunity mechanisms shared by prokaryotes and metazoans

    Gurmeet Kaur, Lakshminarayan M Iyer ... L Aravind
    Prokaryotic TRADD-N and Death-like adaptor domains in diverse predicted apoptosis and immune systems from multicellular prokaryotes and metazoans indicate the common origin of key apoptosis mechanisms required for the stabilization of multicellularity.