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    1. Developmental Biology

    A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development

    Christie Ciarlo, Charles K Kaufman ... Leonard I Zon
    Akt activation is required for neural crest differentiation through regulation of Sox10 activity.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

    Ibrahim Ahmed, Shen-Hsi Yang ... Andrew D Sharrocks
    eRNAs detected in patient-derived transcriptomic data can delineate potential active enhancer regions in oesophageal adenocarcinoma and uncover genes associated with the cancer phenotype.
    1. Cancer Biology

    The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

    Sean W Fanning, Rinath Jeselsohn ... Geoffrey L Greene
    Bazedoxifene's SERD activities enable it to resist the impact of activating ESR1 mutations in breast cancer.
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