10,337 results found
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation

    Susan Martin, Jessica Tyrrell ... Hanieh Yaghootkar
    Using genetics, it is possible to uncouple higher adiposity from its adverse metabolic effects and show that some obesity-associated conditions may benefit from treating the metabolic effects alone, whilst others may benefit more from weight loss.
    1. Medicine
    2. Microbiology and Infectious Disease

    Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

    A Sarah Walker, Emma Pritchard ... COVID-19 Infection Survey team
    Wide variation in cycle threshold (Ct) values from SARS-CoV-2 RT-PCR tests over calendar time offers the potential for their broader use in public testing programmes as an ‘early-warning’ system for shifts in infectious load and hence transmission.
    1. Genetics and Genomics

    Novel genetic loci affecting facial shape variation in humans

    Ziyi Xiong, Gabriela Dankova ... Manfred Kayser
    A comprehensive genome scan of 18,000 multi-ethnic individuals with 3-dimensional facial images highlighted multiple face-associated genetic loci for which regulatory activities in human neural cells were established.
    1. Computational and Systems Biology

    Ecological feedback in quorum-sensing microbial populations can induce heterogeneous production of autoinducers

    Matthias Bauer, Johannes Knebel ... Erwin Frey
    Quorum sensing enables heterogeneous production of autoinducers in microbial populations, suggesting an alternative mechanism to stochastic gene expression in bistable gene-regulatory circuits to control phenotypic heterogeneity.
    1. Developmental Biology

    An important role for triglyceride in regulating spermatogenesis

    Charlotte F Chao, Yanina-Yasmin Pesch ... Elizabeth Rideout
    Triglyceride plays an important role in regulating sperm development.
    1. Evolutionary Biology

    Diversification dynamics in the Neotropics through time, clades, and biogeographic regions

    Andrea S Meseguer, Alice Michel ... Fabien L Condamine
    Neotropical outstanding biodiversity emerged from sustained rates of species accumulation over time, although, for some periods, tetrapods were less successful than plants in keeping pace with a changing environment.
    1. Genetics and Genomics

    Can education be personalised using pupils’ genetic data?

    Tim T Morris, Neil M Davies, George Davey Smith
    Current polygenic scores for education do not provide accurate predictions of educational achievement above other data or at the individual level.
    1. Computational and Systems Biology
    2. Neuroscience

    Place-cell capacity and volatility with grid-like inputs

    Man Yi Yim, Lorenzo A Sadun ... Thibaud Taillefumier
    A very large number of place-field maps can be robustly learned by association of external cues with the grid-driven response, however plasticity in the grid-cell inputs renders the place-cell responses volatile.
    1. Computational and Systems Biology
    2. Neuroscience

    Principles for coding associative memories in a compact neural network

    Christian Pritz, Eyal Itskovits ... Alon Zaslaver
    A compact neural network can form various associative memories that are encoded in a distributed manner, where each neuron stores different components of the memory.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Juxtaposition of heterozygous and homozygous regions causes reciprocal crossover remodelling via interference during Arabidopsis meiosis

    Piotr A Ziolkowski, Luke E Berchowitz ... Ian R Henderson
    Heterozygosity changes the balance between interfering and non-interfering crossovers during Arabidopsis meiosis.

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