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    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon et al.
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Developmental Biology

    DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

    Sebastian Canovas et al.
    Reproductive fluids help the correct establishment of some epigenetic marks and gene expression in preimplantation pig embryos.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Convergence of topological domain boundaries, insulators, and polytene interbands revealed by high-resolution mapping of chromatin contacts in the early Drosophila melanogaster embryo

    Michael R Stadler et al.
    Fruit fly chromosomes are divided into discrete structural domains by regions of decompacted chromatin, suggesting a novel model for the formation of a known class of genetic elements.
    1. Medicine
    2. Microbiology and Infectious Disease

    Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

    A Sarah Walker et al.
    Wide variation in cycle threshold (Ct) values from SARS-CoV-2 RT-PCR tests over calendar time offers the potential for their broader use in public testing programmes as an ‘early-warning’ system for shifts in infectious load and hence transmission.
    1. Cell Biology

    Conformational specificity of opioid receptors is determined by subcellular location irrespective of agonist

    Stephanie E Crilly et al.
    A GPCR activated by the same agonist engages different conformational biosensors at different subcellular locations, suggesting that location-based conformations drive spatial encoding of signaling.
    1. Neuroscience

    Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury

    Nikolay Lukoyanov et al.
    In addition to the well-established involvement of descending neural tracts, the left-right side-specific endocrine mechanism may contribute to signaling from injured brain to spinal motor circuits.
    1. Epidemiology and Global Health
    2. Medicine

    Effects of water, sanitation, handwashing, and nutritional interventions on telomere length among children in a cluster-randomized controlled trial in rural Bangladesh

    Audrie Lin et al.
    In a randomized controlled trial in rural Bangladesh, an intensive, combined water, sanitation, handwashing, and nutrition intervention delivered to compounds of newborn children increased telomere length attrition during their first year of life.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Vasohibin1, a new mouse cardiomyocyte IRES trans-acting factor that regulates translation in early hypoxia

    Fransky Hantelys et al.
    In mouse cardiomyocytes, (lymph)angiogenic growth factors are induced during early hypoxia by a translational mechanism involving a new IRES trans-acting factor, vasohibin-1.
    1. Chromosomes and Gene Expression

    GC content shapes mRNA storage and decay in human cells

    Maïté Courel et al.
    The GC content of human mRNAs is key to P-body localization and protein yield, and has a major impact on their post-transcriptional control.
    1. Cell Biology

    PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

    Insook Jang et al.
    The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.