2,785 results found
    1. Cell Biology
    2. Neuroscience

    The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs

    Thibaut Laboute et al.
    GPR88 inhibits G-protein signaling of nearby GPCRs, and dampens b-arrestin recruitment by all GPCRs tested, likely by sequestration in intracellular compartments.
    1. Structural Biology and Molecular Biophysics

    Molecular basis of signaling specificity between GIRK channels and GPCRs

    Kouki K Touhara, Roderick MacKinnon
    A single kinetic step in the G protein activation cycle determines whether a G protein-coupled receptor activates G protein-gated K+ channels or not.
    1. Cancer Biology
    2. Cell Biology

    GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor

    Jenna L Jewell et al.
    Protein kinase A (PKA) phosphorylates Raptor and inhibits mammalian target of rapamycin complex 1 (mTORC1) activity.
    1. Neuroscience

    Mechanotransduction: Two views of the same stimulus

    Wayne A Johnson
    Signals from two different membrane proteins are combined to modulate how strongly sensory neurons respond to mechanical force.
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    1. Genetics and Genomics

    Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling

    Andres M Lebensohn et al.
    A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.
    1. Neuroscience

    Orphan receptor GPR158 controls stress-induced depression

    Laurie P Sutton et al.
    The orphan receptor GPR158 is highly regulated by stress exposure and acts on key neuronal signaling pathways in the prefrontal cortex to control depressive-like behaviors.
    1. Neuroscience

    RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

    Olga Ostrovskaya et al.
    A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.
    1. Neuroscience

    Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

    Nicole Scholz et al.
    Metabotropic mechanosensing occurs through an adhesion-type G protein-coupled receptor.
    1. Cancer Biology
    2. Cell Biology

    Genome-wide CRISPR screening reveals genetic modifiers of mutant EGFR dependence in human NSCLC

    Hao Zeng et al.
    Functional genomic screening reveals new synthetic lethality with and modes of resistance to epidermal growth factor receptor (EGFR) targeted therapy in EGFR-mutant human lung cancer.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes

    Shuang Yang et al.
    Membrane recruitment of BBSome is coupled to a conformational change, and interaction of the BBSome with GPCR cargoes depends on the GPCRs releasing their amphipathic helix 8 from the membrane.

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