3,560 results found
    1. Cell Biology
    2. Genomics and Evolutionary Biology

    KPNB1 mediates PER/CRY nuclear translocation and circadian clock function

    Yool Lee et al.
    KPNB1 regulates rhythmic spatio-temporal nuclear import of the PER/CRY complex and is required for negative feedback repression in mammalian and fly clock function.
    1. Biochemistry and Chemical Biology
    2. Biophysics and Structural Biology

    Ligand modulation of sidechain dynamics in a wild-type human GPCR

    Lindsay D Clark et al.
    Generation of a highly deuterated 13C-methyl labeled wild-type GPCR sample is used to facilitate characterization of the molecular environments and fast ps-ns dynamics of sidechains when the receptor is bound to ligands of different efficacy.
    1. Human Biology and Medicine
    2. Neuroscience

    A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity

    Yuwei Yao et al.
    A cell-surface receptor called Gpr52 is able to lower the levels of the disease-causing protein mutant huntingtin and suppress its toxicity when knocked-down, making this receptor a promising drug target in Huntington's disease.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Oxyntomodulin regulates resetting of the liver circadian clock by food

    Dominic Landgraf et al.
    The gut-released peptide oxyntomodulin mediates the alignment of liver clock gene and metabolic transcript rhythms with the timing of food intake by postprandial induction of hepatic Per gene expression.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Circadian Rhythms: Feeding time

    Hugh D Piggins , David A Bechtold
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    1. Neuroscience

    Mechanotransduction: Two views of the same stimulus

    Wayne A Johnson
    Signals from two different membrane proteins are combined to modulate how strongly sensory neurons respond to mechanical force.
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    1. Cancer Biology

    Cancer Risk: Why do women with melanoma do better than men?

    Keiran SM Smalley
    Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.
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    1. Neuroscience

    Luqin-like RYamide peptides regulate food-evoked responses in C. elegans

    Hayao Ohno et al.
    Identification and functional characterization of C. elegans luqin-like arginine-tyrosine-NH2 (RYamide) peptides reveal their critical role in feeding-related processes.
    1. Neuroscience

    RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling

    Olga Ostrovskaya et al.
    A critical regulator of inhibitory neurotransmitter signaling in the hippocampus has been identified in experiments on mice and been shown to play essential role in synaptic plasticity and memory.
    1. Neuroscience

    The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans

    Michael J Iannacone et al.
    During sickness, sleep is induced by neuropeptides, which contain an amidated arginine-phenylalanine motif, acting in a neuroendocrine fashion on a G-protein coupled receptor called DMSR-1.

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