Accounting for genetic information improved normative models of hippocampal volume in humans by accounting for change equivalent to around 3 years of normal loss for a person aged 65.

Computational-driven, imaging-based topological profiles of neurodegeneration differ substantially in different neurodegenerative conditions, suggesting distinct modes of dependence of the pathological spread on the underlying connectivity.

Brain-Age delta is a non-invasive marker of biological brain aging that is sensitive to the presence of risk factors and altered biomarkers of Alzheimer's disease in non-demented individuals.

The helical bacterium Helicobacter pylori patterns cell wall synthesis using two distinct cytoskeletal proteins, CcmA and MreB, to achieve its characteristic shape.

METTL3-mediated m6A modification maintains proper cell lineage specification during skin epithelium morphogenesis by coupling transcription and translation of key regulatory pathways.

An unprecedented large-scale screen in mice for morphogenetic regulators of tissue development provides major new insights into the roles of Rho GTPases in diverse array of skin developmental processes.

Phosphorylated tau was related to a loss of structural stability in medial temporal lobe connectivity, and this loss of stability moderated the relationship between phosphorylated tau accumulation and memory decline.

In vivo dopamine neuron imaging-based neuroprotective small molecule screen in larval zebrafish and mechanistic investigation using conditional CRISPR knockout and cell-type-specific RNA-seq analysis, coupled with cross-species analyses including human clinical data interrogation, uncover potential disease-modifying therapeutics for Parkinson's disease (PD).

At optimal concentrations, the ciliary inhibitor Cp110 promotes ciliogenesis by localization to previously uncharacterized sites at the basal body, where it recruits ciliary adhesion complexes that mediate basal body interaction with F-actin networks.

The pattern of atrophy in Parkinson's disease is consistent with the disease spreading via intrinsic brain networks.