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    1. Developmental Biology

    Genetic and physical interactions reveal overlapping and distinct contributions to meiotic double-strand break formation in C. elegans

    Marilina Raices, Fabiola Balmir ... Judith Yanowitz
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cell Biology

    Prolyl dihydroxylation of unassembled uS12/Rps23 regulates fungal hypoxic adaptation

    Sara J Clasen, Wei Shao ... Peter J Espenshade
    The protein uS12/Rps23 functions extra-ribosomally to control oxygen homeostasis in fission yeast.
    1. Neuroscience

    Identification of novel microcephaly-linked protein ABBA that mediates cortical progenitor cell division and corticogenesis through NEDD9-RhoA

    Aurelie Carabalona, Henna Kallo ... Claudio Rivera
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    The connectome of the adult Drosophila mushroom body provides insights into function

    Feng Li, Jack W Lindsey ... Gerald M Rubin
    Analysis of neuronal circuit architecture provides mechanistic insights into what an adult fly can learn, remember, and use to guide its behavior.
    1. Computational and Systems Biology
    2. Developmental Biology

    Unipolar distributions of junctional Myosin II identify cell stripe boundaries that drive cell intercalation throughout Drosophila axis extension

    Robert J Tetley, Guy B Blanchard ... Bénédicte Sanson
    Analysing Myosin II unipolar planar polarisation with high spatial and temporal resolution during Drosophila axis extension reveals how tissue boundaries drive polarized cell intercalation while limiting cell mixing.
    1. Cell Biology
    2. Developmental Biology

    Proliferation-independent regulation of organ size by Fgf/Notch signaling

    Agnė Kozlovskaja-Gumbrienė, Ren Yi ... Tatjana Piotrowski
    Cell adhesion regulates organ size in the zebrafish lateral line system.
    1. Chromosomes and Gene Expression
    2. Cancer Biology

    Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

    Mary Ann Allen, Zdenek Andrysik ... Joaquin M Espinosa
    The first global analysis of the effects of the transcription factor p53 on RNA synthesis illuminates several novels aspects of the molecular mechanism of action of this potent tumor suppressor.
    1. Developmental Biology
    2. Genetics and Genomics

    A genome-wide resource for the analysis of protein localisation in Drosophila

    Mihail Sarov, Christiane Barz ... Frank Schnorrer
    A large-scale transgenic resource enables live imaging, subcellular localisation and interaction proteomics of specific gene products of interest at all stages of Drosophila development.
    1. Developmental Biology
    2. Neuroscience

    Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia

    Laura Fontenas, Sarah Kucenas
    Motor exit point (MEP) glia utilize mechanisms most commonly attributed to neural crest cells for their development from spinal cord precursors.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Mechanisms governing target search and binding dynamics of hypoxia-inducible factors

    Yu Chen, Claudia Cattoglio ... Xavier Darzacq
    Live-cell single particle tracking reveals the intrinsically disordered regions of transcription factors playing an unanticipated role in the nuclear search and chromatin binding process leading to functional target site selectivity and gene activation.
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