51 results found
    1. Epidemiology and Global Health

    Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density

    John Bradley et al.
    Malaria transmission between human and mosquito depends on the number of male and female gametocytes in the blood.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    Modeling the dynamics of Plasmodium falciparum gametocytes in humans during malaria infection

    Pengxing Cao et al.
    A mathematical model of blood-stage infection with Plasmodium falciparum malaria capturing the sexual stage of the parasite life-cycle is validated against human data, providing new insight into human-to-mosquito transmission.
    1. Epidemiology and Global Health

    Predicting mosquito infection from Plasmodium falciparum gametocyte density and estimating the reservoir of infection

    Thomas S Churcher et al.
    Identifying and treating those groups of individuals that are most likely to transmit the malaria parasite to mosquitoes could help to control the spread of the disease.
    1. Microbiology and Infectious Disease

    A randomized feasibility trial comparing four antimalarial drug regimens to induce Plasmodium falciparum gametocytemia in the controlled human malaria infection model

    Isaie J Reuling et al.
    Controlled human malaria infection model allows the study of gametocyte biology and dynamics providing novel insights and tools in malaria transmission and elimination efforts.
    1. Microbiology and Infectious Disease

    Malaria: On a mission to block transmission

    Amanda Ross, Nicolas MB Brancucci
    The controlled infection of volunteers with Plasmodium falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.
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    1. Developmental Biology
    2. Plant Biology

    Three ancient hormonal cues co-ordinate shoot branching in a moss

    Yoan Coudert et al.
    The mosses and angiosperms have independently evolved mechanisms that use the same hormones-auxin, cytokinin and strigolactone-to regulate lateral shoot branching.
    1. Plant Biology

    Convergent recruitment of TALE homeodomain life cycle regulators to direct sporophyte development in land plants and brown algae

    Alok Arun et al.
    TALE homeodomain transcription factors have been independently recruited to regulate gametophyte to sporophyte transitions in two complex multicellular eukaryotic supergroups, land plants in Archaeplastida and brown algae in Chromalveolata.
    1. Plant Biology
    2. Genetics and Genomics

    The Natural History of Model Organisms: Genetic, evolutionary and plant breeding insights from the domestication of maize

    Sarah Hake, Jeffrey Ross-Ibarra
    Comparing maize to its wild ancestor teosinte advances our understanding of how it and other cereal crops evolved, and also identifies the genetic variation that can contribute to important agricultural traits.
    1. Cell Biology

    Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

    Adam J Reid et al.
    Plasmodium parasite transcription shifts dramatically along asexual development, and transmission stages variably express important immune evasion genes, suggesting much interesting biology has until now been hidden by bulk analyses.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Apicomplexan-like parasites are polyphyletic and widely but selectively dependent on cryptic plastid organelles

    Jan Janouškovec et al.
    Apicomplexan-like parasites originated several times independently and many of them contain cryptic plastid organelles, which demonstrate that the parasites evolved from photosynthetic algae.

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