40 results found
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray et al.
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Developmental Biology

    Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling

    Xin Huang et al.
    Post-implantation epiblast maturation and patterning of anterior-posterior axis in mouse embryonic development are mediated by pluripotency transcription factor Zfp281 through transcriptional and epigenetic control of Nodal signaling.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Atrophin controls developmental signaling pathways via interactions with Trithorax-like

    Kelvin Yeung et al.
    ChIP-seq and phenotypic analyses reveal Atrophin from Drosophila directly regulates Notch and Dpp signaling components, and engrailed gene expression, via interactions with GAGA Factor.
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    Structural mechanism of ligand activation in human calcium-sensing receptor

    Yong Geng et al.
    L-amino acids are agonists of calcium-sensing receptor, and act jointly with calcium and phosphate ions to control receptor function.
    1. Neuroscience

    Dbx1 precursor cells are a source of inspiratory XII premotoneurons

    Ann L Revill et al.
    Building on previous work (Wang et al., 2014), we use a combination of genetic, electrophysiology and laser ablation approaches to identify a developmentally defined population of neurons that are a significant source of clinically relevant inspiratory drive to XII motoneurons.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Phenotype inference in an Escherichia coli strain panel

    Marco Galardini et al.
    The mechanistic impact of genetic variants can be combined with previous knowledge on gene function to deliver conditional growth predictions and pave the way for personalized genetic interventions.
    1. Neuroscience

    Emergence of transformation-tolerant representations of visual objects in rat lateral extrastriate cortex

    Sina Tafazoli et al.
    Neuronal recordings from rat visual cortex reveal an object-processing pathway, along which neuronal representations become increasingly capable of supporting recognition of visual objects in spite of variation in their appearance.
    1. Computational and Systems Biology
    2. Neuroscience

    Mapping nonlinear receptive field structure in primate retina at single cone resolution

    Jeremy Freeman et al.
    Multi-electrode recordings and modeling are combined to reveal the transformations of signals from cones to bipolar cells and then to ganglion cells within the primate retina.
    1. Neuroscience

    Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice

    Xueying Wang et al.
    Laser-ablating neurons of a single genetic class reveals that Dbx1-derived interneurons comprise core respiratory rhythmogenic and premotor circuits and provides quantitative cellular parameters that govern network functionality
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim et al.
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.

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