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    1. Human Biology and Medicine

    Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity

    Tingqing Guo et al.
    The ALK7 receptor functions cell-autonomously and homeostatically in adult adipocytes to regulate catecholamine sensitivity in response to the diet.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Fail-safe control of translation initiation by dissociation of eIF2α phosphorylated ternary complexes

    Martin D Jennings et al.
    Phosphorylated translation initiation factor eIF2, a potent inhibitor of protein synthesis in eukaryotic cells, is also inhibitory to protein synthesis when bound to GTP and initiator tRNA broadening the reach and immediacy of eIF2-mediated control.
    1. Neuroscience
    2. Genetics and Genomics

    Regulatory changes in two chemoreceptor genes contribute to a Caenorhabditis elegans QTL for foraging behavior

    Joshua S Greene et al.
    A quantitative trait locus that includes two pheromone receptor genes affects foraging behavior; for one of the genes, the two alleles of the QTL have opposite effects because of distinct sites of expression.
    1. Developmental Biology
    2. Human Biology and Medicine

    Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu et al.
    Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.
    1. Chromosomes and Gene Expression

    Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

    Clémence Hocquet et al.
    Contrary to the generally accepted model, condensin maintains proper gene expression by promoting the accurate segregation of chromosomes and the partitioning of the RNA-exosome throughout mitosis, instead of directly regulating transcription.
    1. Developmental Biology

    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

    Jadiel A Wasson et al.
    Epigenetic reprogramming by LSD1/KDM1A acts at fertilization in mice to enable embryogenesis and prevent behavioural abnormalities.
    1. Developmental Biology

    Specification of diverse cell types during early neurogenesis of the mouse cerebellum

    John W Wizeman et al.
    Single-cell RNA sequencing resolves inter- and intra-population heterogeneity, identifies rare cell types, and reconstructs specification trajectories during early neurogenesis of the mouse cerebellum.
    1. Developmental Biology

    Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

    Rodrigo M Young et al.
    Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion

    Donghyuk Shin et al.
    With monoubiquitination sites of Rab5 identified and structural and biochemical studies using chemically synthesized ubiquitinated Rab5, Rab5 monoubiquitination is found to downregulate the function of Rab5 in a site-dependent manner.
    1. Genetics and Genomics
    2. Human Biology and Medicine

    Epigenetic profiling of growth plate chondrocytes sheds insight into regulatory genetic variation influencing height

    Michael Guo et al.
    Epigenetic profiling of femoral growth plate chondrocytes helps whittle-down GWAS height variants to fewer putative functional variants.