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    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim et al.
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
    1. Developmental Biology
    2. Genetics and Genomics

    The genome of the crustacean Parhyale hawaiensis, a model for animal development, regeneration, immunity and lignocellulose digestion

    Damian Kao et al.
    The first malacostracan genome sequence will establish the genetically tractable Parhyale hawaiensis as a model organism in this key animal group.
    1. Developmental Biology

    The transcription factor Pitx2 positions the embryonic axis and regulates twinning

    Angela Torlopp et al.
    In higher vertebrates, the position of the embryonic axis (the location at which gastrulation starts) is determined by the transcription factor Pitx2, which suggests that the mechanisms of this process, and hence those that regulate twinning, are related to those that set up the left–right axis.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Computational and Systems Biology

    Gene regulatory network reconstruction using single-cell RNA sequencing of barcoded genotypes in diverse environments

    Christopher A Jackson et al.
    Single cell expression data can be used to determine how regulatory transcription factors and target genes are connected, and is especially useful when studying transcription factors controlling heterogeneous cell states.
    1. Developmental Biology

    Specification of diverse cell types during early neurogenesis of the mouse cerebellum

    John W Wizeman et al.
    Single-cell RNA sequencing resolves inter- and intra-population heterogeneity, identifies rare cell types, and reconstructs specification trajectories during early neurogenesis of the mouse cerebellum.
    1. Chromosomes and Gene Expression

    Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

    Clémence Hocquet et al.
    Contrary to the generally accepted model, condensin maintains proper gene expression by promoting the accurate segregation of chromosomes and the partitioning of the RNA-exosome throughout mitosis, instead of directly regulating transcription.
    1. Developmental Biology

    Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

    Rodrigo M Young et al.
    Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
    1. Developmental Biology

    Targeting senescent cells enhances adipogenesis and metabolic function in old age

    Ming Xu et al.
    Senescent cells contribute to age-related fat dysfunction and can directly impair healthy fat progenitor function, in part, via the secretion of activin A.
    1. Developmental Biology

    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

    Jadiel A Wasson et al.
    Epigenetic reprogramming by LSD1/KDM1A acts at fertilization in mice to enable embryogenesis and prevent behavioural abnormalities.