In-lab evolution of synthetic promoters has revealed a novel general mechanism for de novo evolution of gene regulation, and highlights the crucial role of expression noise in this process.

Genetic variation can impact multiple levels of gene regulation and disease through alternative polyadenylation.

When two signals increase transcription of the same gene, their combined effect tends to reflect either the sum of the individual increases or the product of the individual fold-changes.

The myopathic transcription factor DUX4 induces discordant dysregulation of transcript and protein levels, demonstrating a key role for post-transcriptional gene regulation in facioscapulohumeral muscular dystrophy.

The divergence of gene regulation during evolution in yeast traces phylogenetic distance with prominent changes being associated with changes in lifestyle and a whole genome duplication event.

The X-linked loci Firre and Dxz4 are involved in autosomal gene regulation rather than XCI biology.

Silencing of gene regulatory elements by modifications of DNA-bound proteins promotes the progression of early mouse development.

Quantitative analysis of time-dependent transcription data elucidates the signal processing within the genetic network that regulates transcriptional cell cycle oscillations in yeast.

Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.

Differences in promoter affinity and MYC levels explain distinct expression profiles induced by physiological and oncogenic MYC.