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    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Natural changes in light interact with circadian regulation at promoters to control gene expression in cyanobacteria

    Joseph Robert Piechura, Kapil Amarnath, Erin K O'Shea
    Cyanobacteria cope with both predictable day/night changes and natural fluctuations in light during the day by adjusting the expression dynamics of circadian-clock-controlled genes via a network of transcriptional regulators.
    1. Ecology
    2. Genetics and Genomics

    Individual differences in honey bee behavior enabled by plasticity in brain gene regulatory networks

    Beryl M Jones, Vikyath D Rao ... Gene E Robinson
    Integration of automatic behavioral tracking with brain molecular profiling reveals the role of gene regulatory network plasticity in the regulation of behavioral phenotypes.
    1. Genetics and Genomics

    Passive and active DNA methylation and the interplay with genetic variation in gene regulation

    Maria Gutierrez-Arcelus, Tuuli Lappalainen ... Emmanouil T Dermitzakis
    Detailed analysis of umbilical cord cells shows that the associations between DNA methylation, gene expression and genetic variation are complex and context-dependent.
    1. Developmental Biology

    The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

    Aynur Kaya-Çopur, Fabio Marchiano ... Frank Schnorrer
    Muscle fiber growth during development is controlled by the Hippo pathway that links the assembly state of the contractile sarcomeres with the transcriptional state of the sarcomeric genes.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells

    Christopher D Todd, Özgen Deniz ... Miguel R Branco
    Genetic and epigenetic editing experiments establish causal links between transposon-derived enhancers and gene regulation in mouse embryonic and extraembryonic lineages.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

    Ting-Wen Chen, Hsiao-Wei Liao ... Chung-Te Chang
    For mRNA decapping by enhancing DCP2's mRNA-binding affinity and regulating distinct biological processes through DCP1a and DCP1b, human DCP1 is essential.
    1. Genetics and Genomics

    Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells

    Helen M Tauc, Imilce A Rodriguez-Fernandez ... Heinrich Jasper
    Global, multi-angled genetic analyses identified an age-associated loss of stem cell lineage fidelity that was linked to changes in polycomb regulation in the Drosophila intestinal epithelium.
    1. Developmental Biology
    2. Evolutionary Biology

    Multicellularity: The evolution of gene regulation

    Veronica Hinman, Gregory Cary
    The gene regulation mechanisms necessary for the development of complex multicellular animals have been found in sponges.
    Version of Record
    Insight
    1. Cancer Biology
    2. Cell Biology

    Different promoter affinities account for specificity in MYC-dependent gene regulation

    Francesca Lorenzin, Uwe Benary ... Elmar Wolf
    Differences in promoter affinity and MYC levels explain distinct expression profiles induced by physiological and oncogenic MYC.
    1. Microbiology and Infectious Disease

    Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors

    Yuho Murata, Tsubasa Nishi ... Masao Yuda
    Sequential expression of two transcription factors that bind to five- and ten-base female-specific cis-acting elements, respectively, promotes differentiation of Plasmodium female gametocytes.