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Longevity is impacted by growth hormone action during early postnatal period
Liou Y Sun et al.
Transient hormonal alterations during early critical developmental periods can have a crucial and long-lasting effect on lifespan in mice.
Genetics and Genomics
The genetic basis for ecological adaptation of the Atlantic herring revealed by genome sequencing
Alvaro Martinez Barrio et al.
Whole genome sequencing of 19 populations of Atlantic and Baltic herring reveals hundreds of individual loci underlying adaptation to a low salinity niche or timing of reproduction.
Genetics and Genomics
A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe
Benjamin W Okaty et al.
neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
Enhancer architecture sensitizes cell specific responses to
gene dose via a bind and discard mechanism
Yi Kuang et al.
DNA binding site architecture promotes Notch transcription complex degradation to sensitize developmental processes requiring long-duration signaling.
Stem Cells and Regenerative Medicine
Multifaceted secretion of htNSC-derived hypothalamic islets induces survival and antidiabetic effect via peripheral implantation in mice
Yizhe Tang et al.
A subpopulation of multi-secretory hypothalamic stem cells was developed to form 3D spheres for peripheral application against mortality and symptom of a severe diabetes model.
PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity
Insook Jang et al.
The major protein disulfide isomerase family member, PDIA1, is essential in beta cells of mice fed a high-fat diet to maintain glucose homeostasis, proinsulin maturation and organelle integrity.
and the lncRNA
to schedule sexual maturation of the
Hannah Lawson et al.
Genes implicated in the control of mammalian puberty function as components of a molecular clock that determines the timing of sexual differentiation in the
Shank3 modulates sleep and expression of circadian transcription factors
Ashley M Ingiosi et al.
Shank3, a high confidence autism gene candidate, may be a key component of the mechanisms underlying sleep problems in autism.
NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice
Chrysanthi Fergani et al.
Kiss1 neurons and NKB-responsive neurons of the medial amygdala stimulate LH release in females through different (previously unknown) pathways which, in the case of NKB-responsive neurons, are kisspeptin-independent but estradiol-dependent.
Synaptic and peptidergic connectome of a neurosecretory center in the annelid brain
Elizabeth A Williams et al.
A combination of electron microscopic reconstruction and the analysis of single cell transcriptome data is used to reconstruct synaptic and peptidergic signaling networks in a neurosecretory centre.
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