556 results found
    1. Cell Biology
    2. Physics of Living Systems

    Golgi compartments enable controlled biomolecular assembly using promiscuous enzymes

    Anjali Jaiman, Mukund Thattai
    By partitioning promiscuous enzymes across multiple Golgi compartments, eukaryotic cells can tightly control the synthesis of complex sugar oligomers.
    1. Microbiology and Infectious Disease

    Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress

    Elizabeth B Draganova et al.
    Interactions were visualized between the nuclear egress complex from herpes simplex virus and a capsid protein that could promote nucleocytoplasmic translocation of the capsid in infected cells.
    1. Cell Biology

    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

    Abril Angélica Escamilla-Ayala et al.
    Super-resolution microscopy sets a new strategy to comprehend the membrane organization of γ-secretase at single complex resolution identifying nanodomain associations and its diffusion in situ in the living membrane.
    1. Cell Biology

    A microscopy-based kinetic analysis of yeast vacuolar protein sorting

    Jason C Casler, Benjamin S Glick
    In yeast, a fluorescent vacuolar cargo departs from Golgi cisternae early in the TGN stage of maturation, and traffic from prevacuolar endosomes to the vacuole apparently involves a kiss-and-run mechanism.
    1. Cancer Biology

    PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

    Andrä Brunner et al.
    DNA-PK and PTEN protect breast cancer cells from lethal replication stress induced by the WEE1 inhibitor AZD1775 and constitute new potential biomarkers for AZD1775 sensitivity.
    1. Neuroscience
    2. Physics of Living Systems

    Tuning of feedforward control enables stable muscle force-length dynamics after loss of autogenic proprioceptive feedback

    Joanne C Gordon et al.
    Running guinea fowl maintain stable running after loss of the stretch reflex in a major ankle extensor muscle, by increasing feedforward muscle activation to maintain ankle stiffness and work output.
    1. Cell Biology

    G protein-regulated endocytic trafficking of adenylyl cyclase type 9

    André M Lazar et al.
    An adenylyl cyclase isoform is shown to dynamically traffic to endosomes after activation by G protein in mammalian cells, contributing to cellular cAMP signaling by internalized GPCRs.
    1. Cell Biology
    2. Immunology and Inflammation

    Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Emma J Fenech et al.
    Interaction mapping of ubiquitin ligase complexes embedded in the endoplasmic reticulum membrane has identified interactors of RNF26 that influence innate immune signalling.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Membrane characteristics tune activities of endosomal and autophagic human VPS34 complexes

    Yohei Ohashi et al.
    The lipid kinase VPS34 complexes I and II are both activated by unsaturation of substrate and non-substrate lipids, curvature, electrostatics and polyphosphoinositides, which play roles in localisation and cellular function.

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