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    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Functional and structural characterization of an ECF-type ABC transporter for vitamin B12

    Joana A Santos et al.
    ECF-CbrT is a bacterial vitamin B12 transporter that is structurally different from the well-characterized transporter BtuCDF, yet has similar functional properties.
    1. Computational and Systems Biology
    2. Neuroscience

    Flexible theta sequence compression mediated via phase precessing interneurons

    Angus Chadwick et al.
    A new model for phase precession accounts for theta sequence generation, suggests critical roles for interneurons, and predicts circuit properties to optimise memory storage.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Unified single-cell analysis of testis gene regulation and pathology in five mouse strains

    Min Jung et al.
    A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
    1. Developmental Biology

    DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors

    Maria M Mikedis et al.
    DAZL promotes male fertility by enhancing the protein expression of thousands of genes to facilitate expansion and differentiation of transit-amplifying spermatogonia in the testes.
    1. Cell Biology
    2. Computational and Systems Biology

    Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block

    Jakub Tomek et al.
    A computer model of human cardiomyocyte was produced and validated on independent datasets, overcoming shortcomings of its predecessors, also yielding broadly relevant insights and results on major ionic currents.
    1. Developmental Biology

    Macrophages restrict the nephrogenic field and promote endothelial connections during kidney development

    David AD Munro et al.
    Embryonic macrophages encourage early kidney development, interact with developing renal blood vessels, are enriched for mRNAs linked to vascular development, and promote endothelial cross-connections.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary history and genomics of European blackcap migration

    Kira Delmore et al.
    Variation in migration can evolve rapidly and traits that comprise this behaviour may be determined by standing variation at a few regulatory regions that are not common across taxonomic groups.
    1. Ecology
    2. Plant Biology

    Present-day central African forest is a legacy of the 19th century human history

    Julie Morin-Rivat et al.
    The cessation of major anthropogenic disturbances since European colonization in the forests of central Africa leads to a canopy closing, and to the disappearance of certain light-demanding tree species.
    1. Epidemiology and Global Health

    Predicting the likelihood and intensity of mosquito infection from sex specific Plasmodium falciparum gametocyte density

    John Bradley et al.
    Malaria transmission between human and mosquito depends on the number of male and female gametocytes in the blood.
    1. Neuroscience

    Differences in reward biased spatial representations in the lateral septum and hippocampus

    Hannah S Wirtshafter, Matthew A Wilson
    Reward-related spatial information is preferentially represented in the lateral septum compared to the hippocampus and may be used downstream to direct the animal to rewarded locations.