2,045 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

    Ilaria Gori et al.
    The mechanism underlying Shprintzen–Goldberg syndrome is solved and reveals that missense mutations in the transcriptional repressor SKI abolish ligand-induced SKI degradation, which results in attenuation of TGF-β transcriptional responses.
    1. Biochemistry and Chemical Biology
    2. Medicine

    The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

    Omar Al Rifai et al.
    In mice, but not in humans, the bone-derived hormone osteocalcin is O-glycosylated, a post-translational modification controlling its half-life in vivo.
    1. Cancer Biology
    2. Cell Biology

    Ral GTPases promote breast cancer metastasis by controlling biogenesis and organ targeting of exosomes

    Shima Ghoroghi et al.
    A combination of animal models reveal how the molecular mechanisms of exosome secretion (RalA/B-dependent) are linked to their cargo content and their function in breast cancer pre-metastatic niche formation.
    1. Chromosomes and Gene Expression

    The RNA-binding protein SFPQ preserves long-intron splicing and regulates circRNA biogenesis in mammals

    Lotte Victoria Winther Stagsted et al.
    Transcriptome and eCLIP analyses in mouse and human reveal splicing factor proline/glutamine rich (SFPQ) as a conserved and critical guardian of long-intron integrity, splicing, and circular RNA (circRNA) production.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

    Laura J Wagstaff et al.
    In vivo experiments on transgenic mice, and cell culture studies, establish Schwann cell c-Jun as a central regulator of peripheral nerve repair, and repair failure, during aging and chronic denervation.
    1. Ecology
    2. Microbiology and Infectious Disease

    Freshwater monitoring by nanopore sequencing

    Lara Urban et al.
    From now on, nanopore metagenomics can be used to monitor aquatic environments with high spatiotemporal resolution, by use of a benchmarked, standardised and cost-effective workflow.
    1. Neuroscience

    Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network

    Jeong-Kyu Han et al.
    Cerebellar STAT3 is indispensable for proper expression of fear memory network processing.
    1. Developmental Biology

    Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

    Shiri Kult et al.
    The molecular identity of bi-fated tendon-to-bone attachment cells, which display a mixture of transcriptomes of two neighboring cell types, enables the formation of the unique transitional tissue of the enthesis.
    1. Developmental Biology

    Metabolic control of cellular immune-competency by odors in Drosophila

    Sukanya Madhwal et al.
    Impact of odor experience on myeloid metabolism and immunity.
    1. Developmental Biology
    2. Neuroscience

    Dentate gyrus development requires a cortical hem-derived astrocytic scaffold

    Alessia Caramello et al.
    An astrocytic scaffold that depends on SOX9 guides embryonic neuronal progenitors toward the developing dentate gyrus.

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