Investigating reproducibility in preclinical cancer research.

The juxtacrine signaling molecule EphA7, when expressed on terminally-differentiated myocytes, non-cell-autonomously induces adjacent myoblasts to also commit to terminal differentiation leading to rapid coordinated differentiation across the entire population.

The gene Odd-paired is a late-acting regulator of zygotic gene expression, functioning coordinately with Zelda to influence chromatin accessibility and affecting genes expressed along both axes of Drosophila embryos.

Afferent-derived factors control the elaboration of appropriate and robust sizes of dendritic arbors by dynamically modulating dendritic growth parameters.

Interactions between HIV-1 Env and human mannose receptor enhance HIV entry but restrict viral egress and spread in the absence of Vpr.

Combination of experimental mouse models with single-cell RNA-sequencing creates a detailed map of medullary thymic epithelial cell development and identifies a transit-amplifying population as the immediate precursor to Aire-expressing mTECs.

Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.

Escherichia coli is surprisingly tolerant to chromatinization by archaeal histones, suggesting that histones can become established as ubiquitous chromatin proteins without interfering critically with some key DNA-templated processes.

The fish gill, an ever-growing organ with fast turnover rate, displays dedicated stem-cell populations for growth and homeostasis that are interchangeable upon external challenges.

RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.