Browse the search results

Page 3 of 40
    1. Developmental Biology
    2. Neuroscience

    Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies

    Jonathan CY Tang et al.
    A straightforward, rapid and generalizable strategy uses modified nanobodies to convert intracellular protein detection into desired biological activities in cells and animals.
    1. Biochemistry and Chemical Biology

    Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription

    Sarah K Stumper et al.
    Single-molecule observations reveal a mechanism that may be used by multiple competing regulatory proteins to control ribosomal RNA production during rapid bacterial cell growth.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A Y-chromosome shredding gene drive for controlling pest vertebrate populations

    Thomas AA Prowse et al.
    A Y-chromosome shredding gene drive that depletes the pool of XY males and effects mate limitation could be a viable tool for vertebrate pest control.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

    Jürgen Tuvikene et al.
    An evolutionarily conserved neuron-specific and stimulus-dependent enhancer region downstream of the Bdnf exon III regulates the expression of Bdnf transcripts starting from the upstream 5' exons.
    1. Neuroscience

    TUBB4A mutations result in both glial and neuronal degeneration in an H-ABC leukodystrophy mouse model

    Sunetra Sase et al.
    H-ABC leukodystrophy results in neurologic decline, hypomyelination and atrophy of the striatum and cerebellum and Tubb4aD249N/D249Nmouse model recapitulates features of H-ABC disease, providing an important tool for therapeutic development.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference

    Ashley RG Libby et al.
    Dynamic control of intrinsic pluripotent multicellular self-organization to yield robust symmetry breaking patterns that recapitulate morphogenic processes associated with developmental events.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

    Rosa María Marión et al.
    Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
    1. Genetics and Genomics
    2. Neuroscience

    Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

    Alexandra M Stafford et al.
    The trace amine-associated receptor 1 gene has a causal role in methamphetamine intake and thermal response, and interacts with the mu-opioid receptor gene in its methamphetamine addiction-related effects.
    1. Genetics and Genomics
    2. Neuroscience

    Variation in olfactory neuron repertoires is genetically controlled and environmentally modulated

    Ximena Ibarra-Soria et al.
    The neuronal composition of a mouse’s nose is individually unique due to a combination of olfactory experience and genetic variation local to olfactory receptor genes.
    1. Developmental Biology

    Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling

    Megan L Norris et al.
    Elucidation of direct and indirect roles of GPCR signaling during gastrulation.