492 results found
    1. Structural Biology and Molecular Biophysics

    Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer

    Nadia Füllbrunn, Zehao Li ... Changjiang You
    The axial organization and dynamics of the HOPS complex at membrane surface are resolved by graphene-induced energy transfer with subnanometer resolution.
    1. Structural Biology and Molecular Biophysics

    Protein denaturation at the air-water interface and how to prevent it

    Edoardo D'Imprima, Davide Floris ... Werner Kühlbrandt
    Hydrophilized graphene prevents protein denaturation at the air-water interface.
    1. Structural Biology and Molecular Biophysics

    Nanofluidic chips for cryo-EM structure determination from picoliter sample volumes

    Stefan T Huber, Edin Sarajlic ... Arjen J Jakobi
    A novel strategy for reproducible cryo-EM sample preparation with minimal sample volumes.
    1. Developmental Biology

    Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis

    Amandine Jarysta, Abigail LD Tadenev ... Basile Tarchini
    Sensory hair cells in the inner ear use inhibitory G proteins with different regulators at different stages of development to break symmetry, adopt a proper orientation, and grow stereocilia.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

    Swastik Phulera, Hongtao Zhu ... Eric Gouaux
    Structure of the triheteromeric α1β1γ2S GABAA receptor in complex with GABA illuminates the principles of receptor assembly and agonist binding.
    1. Cancer Biology
    2. Neuroscience

    Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

    Jeffrey Barr, Austin Walz ... Paola D Vermeer
    Nerve tracing and behavioral studies in tumor-bearing mice together with transcriptional and functional analysis reveal cancer-induced central and peripheral neuronal alterations that influence behavior.
    1. Neuroscience

    Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing

    Kevin Dorgans, Valérie Demais ... Frédéric Doussau
    Molecular, structural and functional diversity of cerebellar granule cell inputs on single molecular layer interneurons extends information processing in feed-forward inhibition microcircuits.
    1. Structural Biology and Molecular Biophysics

    Structural dynamics of the active HER4 and HER2/HER4 complexes is finely tuned by different growth factors and glycosylation

    Raphael Trenker, Devan Diwanji ... Natalia Jura
    Cryo-EM structures uncover glycosylation in the ectodomains of full-length HER4 homodimer and HER2/HER4 heterodimer complexes, revealing how the binding of various growth factors alters dynamics at the dimerization interface.
    1. Structural Biology and Molecular Biophysics

    Phosphatidic acid modulation of Kv channel voltage sensor function

    Richard K Hite, Joel A Butterwick, Roderick MacKinnon
    Phosphatidic acid influences the gating of voltage-gated K+ channels through a non-specific surface charge mechanism and through a specific interaction between a voltage sensor arginine and the primary phosphate head group on the cytoplasmic membrane leaflet.
    1. Developmental Biology

    A universal reading network and its modulation by writing system and reading ability in French and Chinese children

    Xiaoxia Feng, Irene Altarelli ... Ghislaine Dehaene-Lambertz
    A cross-cultural study of reading acquisition and reading irmpairment reveals the invariance of the neural correlates of reading across cultures.

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