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    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    An elusive electron shuttle from a facultative anaerobe

    Emily Mevers, Lin Su ... Jon Clardy
    The identification of ACNQ as an extracellular electron shuttle solves a longstanding problem in bacterial physiology and provides new tool for bioenergy development.
    1. Cell Biology

    Science Forum: Vision, challenges and opportunities for a Plant Cell Atlas

    Plant Cell Atlas Consortium, Suryatapa Ghosh Jha ... Seung Y Rhee
    A Plant Cell Atlas that shows the location and organization of molecules at cellular and tissue levels could have far-reaching consequences for plant sciences.
    1. Ecology
    2. Genetics and Genomics

    Genomic evidence for global ocean plankton biogeography shaped by large-scale current systems

    Daniel J Richter, Romain Watteaux ... Olivier Jaillon
    Analysis of genomic DNA composition of surface plankton communities reveals a stable, ocean basin-scale plankton biogeography that emerges from the intertwined effects of environmental variations and currents.
    1. Stem Cells and Regenerative Medicine

    Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells

    Balyn W Zaro, Joseph J Noh ... Irving L Weissman
    Mass spectrometry exposes a post-transcriptionally regulated reduction in protein diversity in hematopoietic stem cells, including a lack of detectable Dnmt3a protein levels despite mRNA levels comparable to progenitors.
    1. Chromosomes and Gene Expression

    MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples

    Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Structure of human phagocyte NADPH oxidase in the resting state

    Rui Liu, Kangcheng Song ... Lei Chen
    The cryo-EM structure of a functional human NOX2-p22 complex in nanodisc in the resting state reveals the architecture of this key enzyme essential for innate immunity.
    1. Structural Biology and Molecular Biophysics

    Architectural principles for Hfq/Crc-mediated regulation of gene expression

    Xue Yuan Pei, Tom Dendooven ... Ben F Luisi
    Structural insights show how RNA chaperones cooperate to recognise defined target transcripts and suppress gene expression.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions

    Mark S Lee, Peter J Tuohy ... Michael S Kuhns
    Evolution-guided structure-function analyses reveal that CD4 transmembrane and intracellular juxtamembrane motifs play a more profound role in initiating pMHCII-specific TCR-CD3 signaling than previously characterized CD4-Lck interactions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

    Nicole Monroe, Han Han ... Christopher P Hill
    A cryo-electron microscopy structure of a substrate-bound Vps4-Vta1 AAA ATPase reveals an asymmetric hexameric ring and suggests how nucleotide-induced changes in subunit interfaces translocate polypeptides into the central pore.
    1. Cell Biology
    2. Neuroscience

    Maintenance of neuronal TDP-43 expression requires axonal lysosome transport

    Veronica H Ryan, Sydney Lawton ... Michael E Ward
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing