645 results found
    1. Ecology

    Life Expectancy: Age is just a number

    Hiram Beltrán-Sánchez, Caleb Finch
    The naked mole rat defies the Gompertz law and shows no sign of increased mortality risk as it gets older.
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    1. Human Biology and Medicine
    2. Neuroscience

    Point of View: Predictive regulation and human design

    Peter Sterling
    Why does the human regulatory system, which evolution tuned for small satisfactions, now constantly demand 'more'?
    1. Ecology

    The Natural History of Model Organisms: Peromyscus mice as a model for studying natural variation

    Nicole L Bedford, Hopi E Hoekstra
    The deer mouse (Peromyscus) has emerged as a model system for studying many aspects of biology, supported by extensive historical knowledge of its fascinating and varied natural history.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Cutting Edge: Lessons from Fraxinus, a crowd-sourced citizen science game in genomics

    Ghanasyam Rallapalli et al.
    A citizen science game reveals play interest patterns that could inform crowdsourcing experiment design.
    1. Ecology

    A SLC4 family bicarbonate transporter is critical for intracellular pH regulation and biomineralization in sea urchin embryos

    Marian Y Hu et al.
    Cellular carbon accumulation systems are a fundamental prerequisite for biomineralization to stabilize pH and to supply inorganic carbon for CaCO3 precipitation under changing environmental conditions.
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray et al.
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Cell Biology

    Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates

    Guadalupe Sepulveda et al.
    During centrosome maturation, pericentrin is delivered to the centrosome co-translationally by a microtubule- and dynein-dependent process, as pericentrin mRNA is undergoing active translation near the centrosome.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium

    David R Hill et al.
    Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.
    1. Neuroscience

    Pauses in cholinergic interneuron firing exert an inhibitory control on striatal output in vivo

    Stefano Zucca et al.
    Optogenetics and in vivo recordings in mice reveal that pauses in cholinergic interneurons offer an alternative mechanism to inhibit subthreshold and suprathreshold events of spiny projection neurons.

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