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    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

    Liselot Dewachter, Julien Dénéréaz ... Jan-Willem Veening
    High-throughput single-cell based, genome-wide gene silencing screening (sCRilecs-seq) revealed that drugging the mevalonate pathway resensitizes amoxicillin-resistant pneumococci.
    1. Microbiology and Infectious Disease

    Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression

    Vandana Singh, Scot P Ouellette
    Differentiation of the pathogenic bacterium, Chlamydia trachomatis, from its non-infectious to infectious form is linked to the redox state of the organism.
    1. Microbiology and Infectious Disease

    Quantifying the relationship between SARS-CoV-2 viral load and infectiousness

    Aurélien Marc, Marion Kerioui ... Jeremie Guedj
    Viral dynamic modeling reveals the relationship between SARS-CoV-2 viral load and infectiousness and allows to anticipate the effects of variants of concern and of vaccination on transmission.
    1. Cell Biology
    2. Developmental Biology

    Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress

    Ukrae H Cho, Martin W Hetzer
    The nuclear pore complex is transiently proteolyzed during cell differentiation and the nuclear proteome experience dramatic change.
    1. Evolutionary Biology

    The layered costs and benefits of translational redundancy

    Parth K Raval, Wing Yui Ngan ... Deepa Agashe
    Manipulation of the E. coli translation machinery sheds new light on evolutionary constraints and optimization strategies for bacterial translation and growth.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

    Pelin Ayaz, Sarah Munyoki ... Luke M Rice
    Using linked TOG domains that each bind a curved conformation of αβ-tubulin, a microtubule polymerase catalyzes fast elongation by concentrating αβ-tubulin near the polymer end.
    1. Immunology and Inflammation

    The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation

    Benjamin D Wheeler, John D Gagnon ... K Mark Ansel
    A single microRNA-binding site in a long non-coding RNA alters T cell responses in vivo by 'sponging' the miRNA to inhibit its gene regulatory function.
    1. Developmental Biology
    2. Evolutionary Biology

    Decoupling from yolk sac is required for extraembryonic tissue spreading in the scuttle fly Megaselia abdita

    Francesca Caroti, Everardo González Avalos ... Steffen Lemke
    Extraembryonic tissue spreading in the scuttle fly Megaselia abdita requires mechanical decoupling from the underlying yolk sac.
    1. Cell Biology
    2. Developmental Biology

    DNALI1 interacts with the MEIG1/PACRG complex within the manchette and is required for proper sperm flagellum assembly in mice

    Yi Tian Yap, Wei Li ... Zhibing Zhang
    Axonemal dynein light intermediate polypeptide 1 is required for sperm formation and male fertility through association with MEIG1/PACRG complex in the manchette, involvement in a cargo transport system, intraflagellar transport, and sperm individualization.
    1. Ecology
    2. Genetics and Genomics

    Education and Outreach: March Mammal Madness and the power of narrative in science outreach

    Katie Hinde, Carlos Eduardo G Amorim ... Christopher N Anderson
    Hypothetical battles between animals can be used to interest the general public in biology.