57 results found
    1. Chromosomes and Gene Expression

    Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation

    Assala Lamaa et al.
    The two H2A.Z isoforms have specific interactors which mediate their differential effects on gene expression.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    H2A histone-fold and DNA elements in nucleosome activate SWR1-mediated H2A.Z replacement in budding yeast

    Anand Ranjan et al.
    Specific elements of the canonical nucleosome are recognized by the multi-component SWR1 chromatin remodeler for ATP-dependent replacement of H2A-H2B dimers with H2A.Z-H2B.
    1. Chromosomes and Gene Expression

    Live-cell single particle imaging reveals the role of RNA polymerase II in histone H2A.Z eviction

    Anand Ranjan et al.
    Histone variant H2A.Z is deposited near transcription start sites by the chromatin remodeler SWR1 and seems to be removed by RNA polymerase II at an early stage of transcription elongation.
    1. Chromosomes and Gene Expression

    PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading

    Gergely Rona et al.
    Upon genotoxic stress, the FBXL10-RNF68-RNF2 ubiquitin ligase complex mono-ubiquitylates histone H2A and mediates H2A/H2A.Z exchange to repress transcription and ensures proper high fidelity homologous recombination repair.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Constitutive turnover of histone H2A.Z at yeast promoters requires the preinitiation complex

    Michael Tramantano et al.
    The transcription machinery is required for the disassembly of the promoter-proximal H2A.Z nucleosome, contributing to the constitutive histone turnover at yeast promoters.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    VivosX, a disulfide crosslinking method to capture site-specific, protein-protein interactions in yeast and human cells

    Chitra Mohan et al.
    An in vivo disulfide crosslinking assay shows preferential disassembly of nucleosomes with two H2A.Z histones by transcription machinery in yeast and conjugation to one or two ubiquitin moieties in human cells.
    1. Structural Biology and Molecular Biophysics

    Transcription: Overcoming chromatin barriers

    Babette E de Jong, John van Noort
    Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms

    Alessandro Scacchetti et al.
    Alternative splicing of a single gene generates functional diversity amongst chromatin regulators.
    1. Structural Biology and Molecular Biophysics

    High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

    Zhijie Chen et al.
    Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The Chd1 chromatin remodeler shifts hexasomes unidirectionally

    Robert F Levendosky et al.
    Oriented hexasomes can be generated using the Widom 601 positioning sequence, which enables straightforward production of nucleosomes with asymmetrically modified H2A/H2B dimers.

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