53 results found
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration

    Konstantinos Sousounis et al.
    Experimental manipulation of a core DNA damage response factor and cell-cycle checkpoint regulators reveals a key role for these processes in the progenitor cells that fuel limb regeneration.
    1. Chromosomes and Gene Expression

    Integrated analysis of H2A.Z isoforms function reveals a complex interplay in gene regulation

    Assala Lamaa et al.
    The two H2A.Z isoforms have specific interactors which mediate their differential effects on gene expression.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

    Nealia CM House et al.
    Despite differing by only one amino acid in the C-terminal tail, copy 1 of yeast histone 2A has a repair-specific role not shared by copy 2.
    1. Cell Biology
    2. Genetics and Genomics

    Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

    Maja Kneissig et al.
    A method to generate human cells with massive chromosomal aberrations on a specific chromosome allows analysis of their consequences.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Chromosome territory formation attenuates the translocation potential of cells

    Leah F Rosin et al.
    The translocation potential of cells can be modulated by Condensin II activity during interphase.
    1. Structural Biology and Molecular Biophysics

    High-resolution and high-accuracy topographic and transcriptional maps of the nucleosome barrier

    Zhijie Chen et al.
    Direct observation of RNA Polymerase II transcription through a single nucleosome at near basepair resolution suggests a mechanism for selective control of gene expression.
    1. Structural Biology and Molecular Biophysics

    Transcription: Overcoming chromatin barriers

    Babette E de Jong, John van Noort
    Single-molecule experiments reveal the dynamics of transcription through a nucleosome with single-base-pair accuracy.
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    1. Genetics and Genomics
    2. Plant Biology

    Epigenetic silencing of a multifunctional plant stress regulator

    Mark Zander et al.
    Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    TERRA regulate the transcriptional landscape of pluripotent cells through TRF1-dependent recruitment of PRC2

    Rosa María Marión et al.
    Telomeric TRF1 controls the transcriptional programmes of pluripotent stem cells by recruiting PRC2 to pluripotency and differentiation genes by controlling the expression of those gene sites and the binding of TERRA RNAs to them.
    1. Stem Cells and Regenerative Medicine

    Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade

    Emily J Lodge et al.
    The LATS/YAP/TAZ cascade promotes SOX2+ pituitary stem cell fate and when over-activated, transforms normal stem cells into cancer stem cells.

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