15 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    E3 ubiquitin ligase Bre1 couples sister chromatid cohesion establishment to DNA replication in Saccharomyces cerevisiae

    Wei Zhang et al.
    E3 ubiquitin ligase Bre1-induced H2B monoubiquitination is epigenetically important for recruiting replication factor Mcm10 and cohesion establishment factors Ctf4, Ctf18 and Eco1 to early replication origins to establish sister chromatid cohesion.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics

    Melesse Nune et al.
    The histone chaperone FACT and the deubiquitinating enzyme Ubp10 act in concert to remove ubiquitin from histone H2B in nucleosomes, and likely coordinate nucleosome assembly during DNA replication and transcription.
    1. Plant Biology

    DET1-mediated degradation of a SAGA-like deubiquitination module controls H2Bub homeostasis

    Amr Nassrallah et al.
    Light signaling components interact with a histone H2B deubiquitination module, adjusting chromatin states at global level during Arabidopsis seedling development.
    1. Genetics and Genomics
    2. Plant Biology

    Epigenetic silencing of a multifunctional plant stress regulator

    Mark Zander et al.
    Interplay between histone demethylation and chromatin remodeling shapes the chromatin environment of the essential stress regulator ETHYLENE-INSENSITIVE2.
    1. Chromosomes and Gene Expression

    Histone H2B ubiquitylation represses gametogenesis by opposing RSC-dependent chromatin remodeling at the ste11 master regulator locus

    Philippe Materne et al.
    Building on previous work (Materne et al., 2015), it is shown that the ubiquitylation of histone H2B represses cell differentiation by opposing chromatin remodeling at the promoter of the master regulator of gametogenesis, ste11
    1. Microbiology and Infectious Disease
    2. Plant Biology

    A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility

    Haiyang Li et al.
    PsAvh52 modulates epigenetic modification to enhance the susceptibility of soybean to Phytophthora sojae infection.
    1. Chromosomes and Gene Expression

    Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

    Winnie Tan et al.
    Biochemical reconstitution experiments uncover the ubiquitin-mediated function of a DNA repair protein, key to the understanding of Fanconi Anemia, a cancer-associated bone marrow failure syndrome.
    1. Biochemistry and Chemical Biology

    The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation

    Tyler B Faust et al.
    The HIV-1 Tat protein hijacks host non-degradative ubiquitination to trigger the nuclear import of the transcription elongation factor, P-TEFb.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

    Ryan M McCormack et al.
    Yersinia pseudotuberculosis and enteropathogenic Escherichia coli promote pathogenicity by deamidating the ubiquitin-like protein NEDD8 to block ubiquitin-dependent trafficking of Perforin-2, which is an effector of innate immunity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation

    Claudia C Schmidt et al.
    Doa10, a membrane-embedded ubiquitin ligase, facilitates the removal of membrane proteins from the endoplasmic reticulum and cooperates with the Cdc48 ATPase in this process.

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