370 results found
    1. Structural Biology and Molecular Biophysics

    Molecular architecture of human polycomb repressive complex 2

    Claudio Ciferri et al.
    Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.
    1. Chromosomes and Gene Expression

    Non-canonical TAF complexes regulate active promoters in human embryonic stem cells

    Glenn A Maston et al.
    The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands

    Anca M Farcas et al.
    A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.
    1. Cell Biology
    2. Developmental Biology

    Dual functions of TAF7L in adipocyte differentiation

    Haiying Zhou et al.
    A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

    Hannah K Long et al.
    Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation

    Marc A Kerenyi et al.
    Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.
    1. Chromosomes and Gene Expression

    A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics

    Nicole A Rapicavoli et al.
    A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    A global change in RNA polymerase II pausing during the Drosophila midblastula transition

    Kai Chen et al.
    The first zygotic genes are transcribed without RNA polymerase II pausing from a TATA-enriched promoter.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Hdac6 regulates Tip60-p400 function in stem cells

    Poshen B Chen et al.
    A normally cytoplasmic deacetylase, Hdac6, localizes to the nucleus in embryonic stem cells, where it regulates the essential Tip60-p400 chromatin remodeling complex.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

    Ji-Eun Lee et al.
    MLL4 (KMT2D) is a major mammalian H3K4 mono- and di-methyltransferase that is essential for enhancer activation, cell-type-specific gene expression, and cell differentiation.

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