160 results found
    1. Chromosomes and Gene Expression

    A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

    Chun-Min Shan et al.
    A lysine-to-methionine mutation in histone H3 dominantly blocks histone H3K9 methylation by trapping its methyltransferase.
    1. Stem Cells and Regenerative Medicine

    The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

    Kerstin Schmidt et al.
    The H3K4 methyltransferase Setd1b is intrinsically required for hematopoietic stem and progenitor cell homeostasis and regulates lineage specification in mice.
    1. Chromosomes and Gene Expression

    Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

    Atsuko Shirai et al.
    Suv39h1 chromodomain possesses nucleic acid-binding activity and this activity is coupled with its H3K9 methylation recognition in assembling heterochromatin.
    1. Chromosomes and Gene Expression

    Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1

    Hanneke Vlaming et al.
    The interrogation of histone modifications on DNA barcodes enables efficient and direct screening for epigenetic regulators in thousands of mutants in parallel.
    1. Stem Cells and Regenerative Medicine

    Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

    Fu Yang et al.
    A Drosophila fertility gene is identified that acts as a linker between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development and transposon silencing..
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

    Ji-Eun Lee et al.
    MLL4 (KMT2D) is a major mammalian H3K4 mono- and di-methyltransferase that is essential for enhancer activation, cell-type-specific gene expression, and cell differentiation.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP

    Arunava Roy et al.
    The innate immune DNA sensor IFI16 is in association with H3K9 methyltransferases SUV39H1 and GLP under physiological conditions in the nucleus which facilitates the epigenetic silencing of foreign viral DNA.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

    Victoria E Pedanou et al.
    A large-scale RNA interference screen uncovers a new transcriptional regulatory program involving the histone H3 demethylase KDM3A, which mediates detachment-induced apoptosis (anoikis) in breast epithelial cells.
    1. Biochemistry and Chemical Biology

    The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression

    Chunjing Bian et al.
    Repression of gene expression by the histone methyltransferase G9a is guided by two zinc finger proteins that can recognize consensus sequences in DNA.

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