82 results found
    1. Chromosomes and Gene Expression

    A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading

    Chun-Min Shan et al.
    A lysine-to-methionine mutation in histone H3 dominantly blocks histone H3K9 methylation by trapping its methyltransferase.
    1. Chromosomes and Gene Expression

    Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly

    Atsuko Shirai et al.
    Suv39h1 chromodomain possesses nucleic acid-binding activity and this activity is coupled with its H3K9 methylation recognition in assembling heterochromatin.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L

    Victoria E Pedanou et al.
    A large-scale RNA interference screen uncovers a new transcriptional regulatory program involving the histone H3 demethylase KDM3A, which mediates detachment-induced apoptosis (anoikis) in breast epithelial cells.
    1. Biochemistry and Chemical Biology

    The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression

    Chunjing Bian et al.
    Repression of gene expression by the histone methyltransferase G9a is guided by two zinc finger proteins that can recognize consensus sequences in DNA.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    H3K9me3 is required for inheritance of small RNAs that target a unique subset of newly evolved genes

    Itamar Lev et al.
    In Caenorhabditis elegans histone methylation (H3K9me3) controls the synthesis of heritable small RNAs in a gene-specific manner and thus enables 'flagging' of newly-acquired genes.
    1. Developmental Biology

    Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers

    Nanoka Suzuki et al.
    Arid3a, a component of H3K9 me3 demethylases, regulates regeneration of the proximal nephric tubule through the evolutionarily conserved regeneration signal-response enhancer.
    1. Chromosomes and Gene Expression

    Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

    Rajesh K Yadav et al.
    Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.
    1. Developmental Biology

    Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

    Yun Huang et al.
    Soon after fertilisation, a critical portion of the embryonic genome is switched on through the actions of maternally inherited Stella, in part through controlling the activation of transposable elements.
    1. Neuroscience

    Coordinated control of terminal differentiation and restriction of cellular plasticity

    Tulsi Patel, Oliver Hobert
    Transcription factors that specify the identity of individual neuron types via activating terminal differentiation gene batteries also restrict cellular plasticity via altering the chromatin landscape.

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