Electron microscopy has been used to produce the first three-dimensional image of the PRC2 gene-silencing complex.

The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.

A protein that can recognize regions of DNA with a high proportion of unmethylated CpG dinucleotides, and then recruit polycomb group proteins to these CpG islands, has been identified.

A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.

Islands of non-methylated DNA are shown to perform a similar epigenetic role in many different vertebrate species.

Lysine-specific demethylase 1 (Lsd1) has an essential role during both the early and later stages of blood cell development.

A long non-coding RNA regulates the expression of genes that encode proteins involved in the inflammatory response.

The first zygotic genes are transcribed without RNA polymerase II pausing from a TATA-enriched promoter.

A normally cytoplasmic deacetylase, Hdac6, localizes to the nucleus in embryonic stem cells, where it regulates the essential Tip60-p400 chromatin remodeling complex.

MLL4 (KMT2D) is a major mammalian H3K4 mono- and di-methyltransferase that is essential for enhancer activation, cell-type-specific gene expression, and cell differentiation.