7,913 results found
    1. Epidemiology and Global Health

    Inference of the SARS-CoV-2 generation time using UK household data

    William S Hart, Sam Abbott ... Robin N Thompson
    Updated estimates of the generation time of SARS-CoV-2 infections indicate that the generation time has become shorter.
    1. Epidemiology and Global Health

    High infectiousness immediately before COVID-19 symptom onset highlights the importance of continued contact tracing

    William S Hart, Philip K Maini, Robin N Thompson
    Fitting a mechanistic model to data from SARS-CoV-2 source-recipient pairs generates improved estimates of changes in infectiousness during infection, indicating substantial transmission shortly before symptom onset.
    1. Genetics and Genomics

    Genome-wide mapping in a house mouse hybrid zone reveals hybrid sterility loci and Dobzhansky-Muller interactions

    Leslie M Turner, Bettina Harr
    The genomic regions that cause male hybrids between house mouse subspecies to have low fertility have been identified.
    1. Cancer Biology
    2. Computational and Systems Biology

    Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

    Andrew R Lynch, Nicholas L Arp ... Mark E Burkard
    Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.
    1. Neuroscience

    Recurrent circuit dynamics underlie persistent activity in the macaque frontoparietal network

    Eric Hart, Alexander C Huk
    Simultaneous recordings of neural ensembles in both the frontal and parietal cortices reveal how persistent activity can be maintained in the primate brain during visuospatial working memory.
    1. Cell Biology
    2. Developmental Biology

    The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules

    Emir E Avilés-Pagán, Masatoshi Hara, Terry L Orr-Weaver
    The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

    Lavanya H Palavalli Parsons, Sridevi Challa ... W Lee Kraus
    PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.
    1. Ecology
    2. Evolutionary Biology

    Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community

    Samuel Frederick Mock Hart, Jose Mario Bello Pineda ... Wenying Shou
    Whereas partner-serving phenotype is intuitively quantified as benefit release rate, molecular genetics revealed an example where this thinking fails, motivating a more general metric.
    1. Developmental Biology

    Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition

    Masatoshi Hara, Sebastian Lourido ... Terry L Orr-Weaver
    The threonine kinase controls maternal mRNA translation phosphorylate components of the translational machinery, including translational repressors, which appear to inactivate to promote the oocyte-to-embryo transition.
    1. Computational and Systems Biology
    2. Developmental Biology

    Untwisting the Caenorhabditis elegans embryo

    Ryan Patrick Christensen, Alexandra Bokinsky ... Hari Shroff
    Open-source software can untwist images of live Caenorhabditis elegans embryos, allowing epidermal and neuronal cell position and morphology to be examined in previously inaccessible developmental time periods.

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