The newly developed antibody-free techniques, HepG4-seq for G-quadruplexes and HBD-seq for R-loops, robustly reveal the comprehensive maps of native G-quadruplexes and R-loops, as well as their roles in transcriptional regulation.

Gene-editing to repair non-functional transcriptional elements in the endogenous promoter of δ-globin increases overall expression of adult hemoglobin 2 (HbA2), providing proof-of-concept for a therapeutic avenue to treat β-hemoglobinopathies.

Resurrected Steller’s sea cow hemoglobin exhibits novel functional traits underlying their adaptation to the sub-Arctic.

Live-cell microscopy and genome-wide screens reveal how slow transitions in metabolism can underlie metabolic memory, providing a model for organisms demonstrating similar history-dependent behaviour and routes to improve industrial microbes.

Contact with bacteria and subsequent hypoxia promotes functional maturation of the immature gastrointestinal tract.

The 3'HS1 CTCF binding site directly modulates chromosomal loops to regulate γ-globin expression through the accession of the hereditary persistence of fetal hemoglobin enhancer.

Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.

Heme-dependent feedback inhibition of rate-limiting ALA-synthesis of plant tetrapyrrole biosynthesis depends on binding of heme to glutamyl-tRNA reductase-binding protein.

Proximity biotinylation of the Drosophila centromere suggests a role of RNA helicases, centromeric transcripts, and centromeric R-loops for centromere function.