4,140 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Interferon lambda 4 impacts the genetic diversity of hepatitis C virus

    M Azim Ansari et al.
    Interferon lambda 4, a protein part of the innate immune response, drives major amino acids selection in patients chronically infected with hepatitis C virus.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Zinc finger protein Zfp335 is required for the formation of the naïve T cell compartment

    Brenda Y Han et al.
    A novel zinc finger transcription factor regulates expression of multiple genes in late stage thymocytes and recent thymic emigrants to promote formation of the naïve T cell compartment.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

    Han Han et al.
    Structural and biochemical studies indicate that AAA+ ATPase employ a general mechanism to translocate a variety of substrates, including extended polypeptides, hairpins, crosslinked chains, and chains conjugated to other molecules.
    1. Neuroscience

    Structured inhibitory activity dynamics in new virtual environments

    Moises Arriaga, Edward B Han
    Inhibitory interneuron activity is dynamically modulated in new environments while individual interneurons show consistent levels of activity modulation across multiple environments, suggesting functional specialization of inhibitory subnetworks.
    1. Structural Biology and Molecular Biophysics

    The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

    Alessandro Porro et al.
    Experimental and computational approaches reveal how ligand binding is coupled to voltage sensing in a HCN channels.
    1. Neuroscience

    Comprehensive machine learning analysis of Hydra behavior reveals a stable basal behavioral repertoire

    Shuting Han et al.
    A novel automated behavior analysis method for Hydra identifies pre-defined and new behavior types, and reveals a stable behavior repertoire.
    1. Neuroscience

    Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data

    Samuel A Neymotin et al.
    Human Neocortical Neurosolver is a new user-friendly software tool for researchers to develop and test hypotheses on cellular/circuit origins of human MEG/EEG signals using a biophysical model.
    1. Neuroscience

    Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

    Shuang Li et al.
    Mice that successfully avoid developing tinnitus despite exposure to excessive noise show spontaneous recovery of KCNQ2/3 potassium channel activity associated with a reduction in HCN channel activity in auditory brainstem neurons.
    1. Developmental Biology

    NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

    Dandan Han et al.
    NEIL DNA glycosylases are required to counteract oxidative base damages within the mitochondrial genome to safeguard neural crest cell differentiation.
    1. Neuroscience

    HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress

    Peng Zhong et al.
    HCN2 channels in the ventral tegmental area play an important role in the pathophysiology of chronic mild stress-induced behavioral deficits.

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