Experimental and computational approaches reveal how ligand binding is coupled to voltage sensing in a HCN channels.

A new analysis algorithm (DISC) enables accurate analysis of data from high-throughput single-molecule paradigms and reveals a non-cooperative binding mechanism of cyclic nucleotide-binding domains from HCN ion channels.

Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.

Using a short peptide to regulate the activity of HCN ion channels illustrates how physiological modulators could inspire new drugs. .

Key numbers about the biology of the SARS-CoV-2 virus and the infection of a single human host by the virus have been compiled from the peer-reviewed literature.

What can authors and reviewers do to keep common statistical mistakes out of the literature?

Open data provides an opportunity to perform new analyses on preexisting data, but trade-offs are required to limit an increase in false positives.

Mass spectrometry has potential as a tool for ecological studies and bioprospecting of natural products from marine cyanobacteria and algae.

The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.