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    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

    Amy Tresenrider, Marcus Hooper ... Thomas A Reh
    An in vitro chemical screen with single-cell sequencing output leads to the identification of Metformin as an in vivo enhancer of Muller glia to neuron reprogramming in mice.
    1. Cell Biology

    Calcium tunneling through the ER and transfer to other organelles for optimal signaling in Toxoplasma gondii

    Zhu-Hong Li, Beejan Asady ... Silvia NJ Moreno
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    PfMORC protein regulates chromatin accessibility and transcriptional repression in the human malaria parasite, Plasmodium falciparum

    Zeinab M Chahine, Mohit Gupta ... Karine G Le Roch
    The PfMORC protein is proven to play a crucial role in chromatin structure, gene regulation and heterochromatin stability, categorizing PfMORC as a strong potential candidate for novel therapeutic interventions.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    An H3-K9-me-independent binding of Swi6/HP1 to siRNA-DNA hybrids initiates heterochromatin assembly at cognate dg-dh repeats in Fission Yeast

    Jyotsna Kumar, Swati Haldar ... Jagmohan Singh
    Not revised
    Reviewed Preprint v1
    • Inadequate
    1. Cancer Biology

    CPT1A mediates radiation sensitivity in colorectal cancer

    Zhenhui Chen, Lu Yu ... Yi Ding
    CPT1A downregulation enhances radioresistance in colorectal cancer (CRC) via FOXM1-mediated antioxidant response, making it a potential biomarker for radiosensitivity and a novel target for improving CRC radiotherapy.
    1. Cancer Biology

    Molecular consequences of acute versus chronic CDK12 loss in prostate carcinoma nominates distinct therapeutic strategies

    Sander Frank, Thomas Persse ... Peter S Nelson
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Immunology and Inflammation

    CXXC-finger protein 1 associates with FOXP3 to stabilize homeostasis and suppressive functions of regulatory T cells

    Xiaoyu Meng, Yezhang Zhu ... Lie Wang
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Functional characteristics and computational model of abundant hyperactive loci in the human genome

    Sanjarbek Hudaiberdiev, Ivan Ovcharenko
    Large-scale multi-omics analysis of genomic high-occupancy target regions in humans suggests involvement of large transcriptional condensates.
    1. Biochemistry and Chemical Biology

    Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

    Jonathan G Van Vranken, Jiaming Li ... Devin K Schweppe
    An approachable framework for the scalable implementation of proteome-wide thermal shift assays to assess drug mechanisms of action.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    MuSK-BMP signaling in adult muscle stem cells maintains quiescence and regulates myofiber size

    Laura A Madigan, Diego Jaime ... Justin R Fallon
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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