Structure of lecithin:cholesterol acyltransferase with a covalent acyl-intermediate mimic and a small molecule activator reveals an active conformation and that the enzyme can be activated via its membrane binding domain.

Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.

The availability of an essential dietary micronutrient is evaluated by an intestinal signaling system that in turn regulates food-uptake and response behaviors by modulating protease expression.

The development of diet-dependent obesity results in the deterioration of calcium homeostasis in pro-opiomelanocortin-expressing neurons and impaired function of the same neurons.

EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.

Bioinformatics and experimental approaches identify families of membrane proteins requiring the co-ordinated action of the Sec pathway and Tat pathways for their integration and define features of the polypeptides that mediate interaction with these pathways.

Molecular signals from chloroplasts can synergistically interact with the plant hormone, abscisic acid (ABA), to regulate non-canonical signaling pathways mediating fundamental cellular processes including stomatal closure, seed dormancy and germination.

Building on previous work (Liu et al., 2015), it is shown that depletion or rescue of adult skeletal muscle stem cells is sufficient to induce or attenuate age-associated neuromuscular junction deterioration respectively.

A phylum-specific ATP synthase subunit is needed for proper mitochondrial function and stability of the complex in Toxoplasma gondii.

Engagement of both host and parasite signaling pathways proves a novel approach for developing improved anti-parasitic therapies.