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    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Protein sequences bound to mineral surfaces persist into deep time

    Beatrice Demarchi et al.
    A chemically unstable ostrich eggshell peptide survives for at least 3.8 million years at the equator, stabilized by strong mineral interactions.
    1. Neuroscience

    Cell-intrinsic mechanisms of temperature compensation in a grasshopper sensory receptor neuron

    Frederic A Roemschied et al.
    The firing rates of neurons in the grasshopper auditory system are surprisingly robust to changes in temperature, and cell-intrinsic mechanisms are sufficient to explain this temperature insensitivity.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis

    Wenn-Chyau Lee et al.
    Plasmodium parasites use host-derived factors to form more rosettes and hamper phagocytosis, representing a new escape mechanism for the malaria parasites.
    1. Neuroscience

    Magnetothermal genetic deep brain stimulation of motor behaviors in awake, freely moving mice

    Rahul Munshi et al.
    Magnetothermal neuromodulation providing quick, tetherless, precise on and off switching of neurons deep in the brain of freely moving animals is orthogonal to optogenetics and a breakthrough in remote modulation techniques.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Target DNA bending by the Mu transpososome promotes careful transposition and prevents its reversal

    James R Fuller, Phoebe A Rice
    Biochemical data demonstrate that the conformation of the target site DNA can dramatically modulate the kinetics and directionality of the otherwise isoenergetic transposition reaction of DDE transposases.
    1. Microbiology and Infectious Disease

    Saliva TwoStep for rapid detection of asymptomatic SARS-CoV-2 carriers

    Qing Yang et al.
    A quick and portable test makes saliva samples turn yellow when people are carrying SARS-CoV-2, the virus that causes COVID-19.
    1. Genetics and Genomics
    2. Medicine

    PTPRG is an ischemia risk locus essential for HCO3-dependent regulation of endothelial function and tissue perfusion

    Kristoffer B Hansen et al.
    HCO3-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
    1. Structural Biology and Molecular Biophysics
    2. Neuroscience

    Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

    Daniel L Kober et al.
    Structural, biophysical, and functional analyses reveal that mutations in TREM2 trigger either misfolding or reduced binding to cell-surface glycosaminoglycans, which segregate with neurodegenerative disease link and highlight a functional surface linked to the pathogenesis of Alzheimer's disease.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila

    Luke Stephen Tain et al.
    Multi-omic profiling of gene expression in response to reduced insulin/IGF-like-signalling reveals tissue-specific regulation of DNA damage and lysosomal mannosidase regulation of tissue homeostasis as pro-longevity responses.
    1. Neuroscience

    Thermotaxis: Some like it hot, but not too hot

    Chloe Greppi et al.
    Insight
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