The therapeutic effects of the sleeping pill zolpidem in patients with disorders of consciousness may be due to recruitment of brain cells idling in abnormally low-frequency brain waves.

The elongation rate of RNA Polymerase II varies greatly between and along genes, as this enzyme accelerates from stable pausing to rapid elongation within genes, and is influenced by CG-content, exons and chromatin.

A technique called meta3C provides an elegant and integrated approach to metagenomic analysis by allowing the de novo assembly, scaffolding and 3D characterization of unknown genomes from a complex mix of species

Lattice light-sheet single-molecule imaging shows 3D Sox2 enhancer clusters in live embryonic stem cells and reveals a model linking 3D spatial distribution of cis-elements, differential target search features and localized gene regulation.

Loss of polarity in epithelial cells leads to mitogenic cytokine upregulation, via coincident activation by JNK and atypical protein kinase C (aPKC), and Polycomb derepression.

Excess membrane can trap outgoing extracellular matrix proteins in secreting cells, leading to pericellular deposits that cause tissue damage.

The pattern of atrophy in Parkinson's disease is consistent with the disease spreading via intrinsic brain networks.

A G protein in striatal neurons forms preassembled complexes with its downstream enzyme, adenylyl cyclase, which has implications for the pathophysiology of movement disorders.

Endogenous virus sequences in the genomes of modern mammals reveal the global spread of an ancient virus lineage, including frequent interspecies transmission, adaptation, and emergence spanning several million years of mammalian evolution

A text-mining study suggests that about half of the papers reporting the results of experiments on mice do not report the sex and age of the mice.