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To establish membrane contacts between its vacuole and the endoplasmic reticulum, the obligate intracellular bacterial pathogen Chlamydia trachomatis has evolved complex molecular strategies to mimic emerging regulatory processes that control contact-dependent organelle–organelle communication.

Loss of polarity in epithelial cells leads to mitogenic cytokine upregulation, via coincident activation by JNK and atypical protein kinase C (aPKC), and Polycomb derepression.

Musashi-mediated post-transcriptional mechanisms regulate glucuronoxylan modification and secondary cell wall formation in the supportive fibre cells of stem in plants.

A postsynaptic, intracellular, scaffolding protein is necessary to build neuronal gap junctions, revealing an unanticipated complexity of molecular and functional organization of electrical synapses.

Left-hander's atypical language brain organization, revealed by task-induced rightward asymmetry, is underpinned at rest by homotopic networks wired for language bilaterally and strong intrinsic connectivity through a large corpus callosum.

Autophagic flux assays in the nematode Caenorhabditis elegans suggest that autophagy decreases during normal aging, whereas long-lived daf-2 and glp-1 mutants maintain autophagic capacity in distinct spatiotemporal-specific manners to extend lifespan.

The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to present day.

Innate antiviral factors do not always perfectly distinguish between self and foreign, and potential adverse effects of antiviral defense mechanisms for the host have been discussed.