Analysis of protein content and protein composition of the ChAdOx1 nCov-19 vaccine, but not of the Ad26.COV2.S vaccine, indicated significantly higher than expected levels of host cell proteins (HCPs) and of free viral proteins.
Alexandre Chojnowski, Peh Fern Ong ... Oliver Dreesen
Expression of the lamina-associated polypeptide α (LAP2α) prevents premature cellular ageing caused by expression of progerin in Hutchinson-Gilford progeria syndrome.
The signaling requirements to decouple proliferation of pancreatic progenitors from differentiation were elucidated and employed for the reproducible expansion, under GMP-compliant conditions, of pancreatic progenitors derived from different human pluripotent stem cell lines.
The cohesin loading factor Scc2/Nipbl interacts frequently with cohesin after the loading reaction in a manner consistent with a role in stimulating loop extrusion.
Rigorous assays of membrane fusion show that a distinct tethering step is required for lumenal compartment mixing in a manner that extends beyond simply increasing the amount of total trans-SNARE complex.
High-resolution GPS data revealed a quadratic relationship between group size and movement, with vulturine guineafowl groups of intermediate size exhibiting the largest home-range size and greater variation in site use.
Alexandria N Miller, Patrick R Houlihan ... David E Clapham
SARS coronaviruses encode several mysterious proteins such as Orf3a and, in contrast to what has been claimed, Orf3a is not an ion channel but rather disrupts cellular trafficking by binding to the protein sorting complex known as HOPS.
