244 results found
    1. Microbiology and Infectious Disease
    2. Genetics and Genomics

    Dissection of the in vitro developmental program of Hammondia hammondi reveals a link between stress sensitivity and life cycle flexibility in Toxoplasma gondii

    Sarah L Sokol, Abby S Primack ... Jon P Boyle
    A derived stress response trait may have contributed to the emergence of a globally dominant and promiscuous parasite.
    1. Microbiology and Infectious Disease

    The flagellar motor of Vibrio alginolyticus undergoes major structural remodeling during rotational switching

    Brittany L Carroll, Tatsuro Nishikino ... Jun Liu
    In situ structures of the flagellar motors genetically docked in CCW and CW rotational states reveal major rearrangement that facilitates rotational switch in Vibrio alginolyticus..
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Cryo electron tomography with volta phase plate reveals novel structural foundations of the 96-nm axonemal repeat in the pathogen Trypanosoma brucei

    Simon Imhof, Jiayan Zhang ... Kent L Hill
    Cryo electron tomography provides the first high-resolution 3D axoneme structure from any pathogenic organism, revealing novel structures that support the unique motility of these pathogens through host tissues.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome

    Eileen P Hamilton, Aurélie Kapusta ... Robert S Coyne
    The model organism Tetrahymena thermopile carries two nuclei with distinct genomes: an unrearranged germline genome with five chromosomes, and a somatic genome reduced in size by a third and with 181 chromosomes.
    1. Cell Biology
    2. Physics of Living Systems

    A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale

    Xarxa Quiroga, Nikhil Walani ... Pere Roca-Cusachs
    Cell stretch release generates plasma membrane (PM) evaginations of ≈100 nm, triggering a local event of actin polymerization that flattens and recovers PM shape.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The infection-tolerant white-footed deermouse tempers interferon responses to endotoxin in comparison to the mouse and rat

    Ana Milovic, Jonathan V Duong, Alan G Barbour
    Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.
    1. Microbiology and Infectious Disease

    The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

    Gang Ye, Joseph Gallant ... Fang Li
    Potent and low-cost Nanosota-1 drug candidates block SARS-CoV-2 infections in vitro and in animal models and act preventively and therapeutically.
    1. Immunology and Inflammation

    Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

    Daniel J Rawle, Thuy T Le ... Andreas Suhrbier
    Granzyme A-/- mice, which have contributed to a body of research into this enzyme, emerge to have a mixed C57BL/6J-C57BL/6N genetic background, compromising our understanding of granzyme A and highlighting a widespread problem for knockout mouse studies generally.
    1. Neuroscience

    Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

    David Moreno-Delgado, Mar Puigdellívol ... Peter J McCormick
    Progression of Huntington's disease can be slowed by altering dopamine signalling through the Dopamine 1 receptor - Histamine 3 receptor heteromer.

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